Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions
Background. The increasing incidence of skin cancers in fair-skinned population and its relatively good response to treatment make its accurate diagnosis of great importance. We evaluated the accuracy of clinical diagnosis of malignant skin lesions by comparing the clinical diagnosis with histologic...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/6618990 |
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| author | Maral Seyed Ahadi Alireza Firooz Hoda Rahimi Mehrdad Jafari Zohreh Tehranchinia |
| author_facet | Maral Seyed Ahadi Alireza Firooz Hoda Rahimi Mehrdad Jafari Zohreh Tehranchinia |
| author_sort | Maral Seyed Ahadi |
| collection | DOAJ |
| description | Background. The increasing incidence of skin cancers in fair-skinned population and its relatively good response to treatment make its accurate diagnosis of great importance. We evaluated the accuracy of clinical diagnosis of malignant skin lesions by comparing the clinical diagnosis with histological diagnosis as the gold standard. Materials and Methods. In this retrospective study, we assessed all the pathology reports from specimens sent to a university hospital laboratory in 3 consecutive years from March 2008 to March 2010. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and positive and negative likelihood ratios were calculated for clinical diagnosis of malignant skin lesions stratified by their histological subtype. Results. A total 4,123 specimen were evaluated. The sensitivity and specificity for clinical diagnosis of malignancy were 90.48% and 82.85%, respectively, whereas the negative predictive value was shown to be 99.06%. The positive and negative likelihood ratios were 5.23 and 0.11, respectively. Conclusion. Pathological assessment of skin lesions remains the cornerstone of skin cancer diagnosis. The high NPV and the relatively low PPV indicate that clinical diagnosis is more efficient in ruling out malignancies rather than diagnosing them. |
| format | Article |
| id | doaj-art-70d42e21837b4d53a1ff77e6ac27f895 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-70d42e21837b4d53a1ff77e6ac27f8952025-02-03T05:52:56ZengWileyDermatology Research and Practice1687-61051687-61132021-01-01202110.1155/2021/66189906618990Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin LesionsMaral Seyed Ahadi0Alireza Firooz1Hoda Rahimi2Mehrdad Jafari3Zohreh Tehranchinia4Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranCenter for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences, Tehran, IranSkin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Otorhinolaryngology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranSkin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground. The increasing incidence of skin cancers in fair-skinned population and its relatively good response to treatment make its accurate diagnosis of great importance. We evaluated the accuracy of clinical diagnosis of malignant skin lesions by comparing the clinical diagnosis with histological diagnosis as the gold standard. Materials and Methods. In this retrospective study, we assessed all the pathology reports from specimens sent to a university hospital laboratory in 3 consecutive years from March 2008 to March 2010. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and positive and negative likelihood ratios were calculated for clinical diagnosis of malignant skin lesions stratified by their histological subtype. Results. A total 4,123 specimen were evaluated. The sensitivity and specificity for clinical diagnosis of malignancy were 90.48% and 82.85%, respectively, whereas the negative predictive value was shown to be 99.06%. The positive and negative likelihood ratios were 5.23 and 0.11, respectively. Conclusion. Pathological assessment of skin lesions remains the cornerstone of skin cancer diagnosis. The high NPV and the relatively low PPV indicate that clinical diagnosis is more efficient in ruling out malignancies rather than diagnosing them.http://dx.doi.org/10.1155/2021/6618990 |
| spellingShingle | Maral Seyed Ahadi Alireza Firooz Hoda Rahimi Mehrdad Jafari Zohreh Tehranchinia Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions Dermatology Research and Practice |
| title | Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions |
| title_full | Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions |
| title_fullStr | Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions |
| title_full_unstemmed | Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions |
| title_short | Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions |
| title_sort | clinical diagnosis has a high negative predictive value in evaluation of malignant skin lesions |
| url | http://dx.doi.org/10.1155/2021/6618990 |
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