Hypolipidemic Effects of Eryngium Caucasicum Leaves Extract on Rats with Induced Diabetes Mellitus
This research aimed to assess the hypolipidemic effects of an extract from Eryngium caucasicum in a Rat model of Type 2 Diabetes Mellitus produced by Streptozotocin. Forty adult male Wistar rats were divided into five groups, with a total of eight rats in each: (1) healthy control rats, (2) diabetic...
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College of Veterinary Medicine, University of Fallujah
2024-02-01
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| Series: | مجلة الانبار للعلوم البيطرية |
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| Online Access: | https://www.anbarjvs.edu.iq/?mno=206916 |
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| author | Glaucio Dire Feliciano |
| author_facet | Glaucio Dire Feliciano |
| author_sort | Glaucio Dire Feliciano |
| collection | DOAJ |
| description | This research aimed to assess the hypolipidemic effects of an extract from Eryngium caucasicum in a Rat model of Type 2 Diabetes Mellitus produced by Streptozotocin.
Forty adult male Wistar rats were divided into five groups, with a total of eight rats in each: (1) healthy control rats, (2) diabetic rats with no diabetes, (3) diabetic rats given insulin, (4) diabetic rats given 200 mg/kg orally for 30 days of Eryngium caucasicum extract, and (5) diabetic rats given 300 mg/kg orally for 30 days. Injecting Nicotinamide and Streptozotocin intraperitoneally caused diabetes. Fasting blood sugar, hepatic enzymes, and lipid profiles were determined from blood samples taken after the trial. The levels of HDL were increased significantly in G3, G4, and G5 compared to G2. The insulin group and the group given 300 mg/kg of Eryngium caucasicum substantially reduced LDL cholesterol compared to the G2. It should be mentioned that the diabetic control group had higher TC compared to the healthy control group after rat diabetes induction (P = 0.020). Compared to the G2, G3 treated with insulin and groups treated with extract at dosages of 200 as well as 300 mg/kg body weight had a substantially lower TC (P < 0.01). Serum TG was improved when insulin and Eryngium caucasicum extract were administered at 200 and 300 mg/kg dosages, respectively (P < 0.05). Serum ALT and AST levels were shown to be elevated after STZ diabetes induction as compared to the G1. Even though diabetic rats' ALT and AST levels were enhanced by insulin and all 2 plant trial dosages, 200 and 300 mg/kg. In summary, our findings suggest that the antidiabetic, hypolipidemic, and hepato-protective properties of Eryngium caucasicum, when administered to an animal model of Type 2 diabetes mellitus, may vary with dosage. [AJVS 2024; 17(2.000): 1-7] |
| format | Article |
| id | doaj-art-70b4cfd9ea614aaabce8a23b3959fed1 |
| institution | Kabale University |
| issn | 1999-6527 2707-0603 |
| language | Arabic |
| publishDate | 2024-02-01 |
| publisher | College of Veterinary Medicine, University of Fallujah |
| record_format | Article |
| series | مجلة الانبار للعلوم البيطرية |
| spelling | doaj-art-70b4cfd9ea614aaabce8a23b3959fed12024-12-14T06:44:49ZaraCollege of Veterinary Medicine, University of Fallujahمجلة الانبار للعلوم البيطرية1999-65272707-06032024-02-011721710.37940/AJVS.2024.17.2.1206916Hypolipidemic Effects of Eryngium Caucasicum Leaves Extract on Rats with Induced Diabetes MellitusGlaucio Dire Feliciano0Laboratory of Chemical and Biological Analysis (LAQB), Foundation State University Center of the West Zone (UEZO), Avenue Manuel Caldeira de Alvarenga, 1203, Campo Grande, Rio de Janeiro, 23070-200, Brazil.This research aimed to assess the hypolipidemic effects of an extract from Eryngium caucasicum in a Rat model of Type 2 Diabetes Mellitus produced by Streptozotocin. Forty adult male Wistar rats were divided into five groups, with a total of eight rats in each: (1) healthy control rats, (2) diabetic rats with no diabetes, (3) diabetic rats given insulin, (4) diabetic rats given 200 mg/kg orally for 30 days of Eryngium caucasicum extract, and (5) diabetic rats given 300 mg/kg orally for 30 days. Injecting Nicotinamide and Streptozotocin intraperitoneally caused diabetes. Fasting blood sugar, hepatic enzymes, and lipid profiles were determined from blood samples taken after the trial. The levels of HDL were increased significantly in G3, G4, and G5 compared to G2. The insulin group and the group given 300 mg/kg of Eryngium caucasicum substantially reduced LDL cholesterol compared to the G2. It should be mentioned that the diabetic control group had higher TC compared to the healthy control group after rat diabetes induction (P = 0.020). Compared to the G2, G3 treated with insulin and groups treated with extract at dosages of 200 as well as 300 mg/kg body weight had a substantially lower TC (P < 0.01). Serum TG was improved when insulin and Eryngium caucasicum extract were administered at 200 and 300 mg/kg dosages, respectively (P < 0.05). Serum ALT and AST levels were shown to be elevated after STZ diabetes induction as compared to the G1. Even though diabetic rats' ALT and AST levels were enhanced by insulin and all 2 plant trial dosages, 200 and 300 mg/kg. In summary, our findings suggest that the antidiabetic, hypolipidemic, and hepato-protective properties of Eryngium caucasicum, when administered to an animal model of Type 2 diabetes mellitus, may vary with dosage. [AJVS 2024; 17(2.000): 1-7]https://www.anbarjvs.edu.iq/?mno=206916eryngium caucasicumstzdiabetesliver function and hypolipidemia |
| spellingShingle | Glaucio Dire Feliciano Hypolipidemic Effects of Eryngium Caucasicum Leaves Extract on Rats with Induced Diabetes Mellitus مجلة الانبار للعلوم البيطرية eryngium caucasicum stz diabetes liver function and hypolipidemia |
| title | Hypolipidemic Effects of Eryngium Caucasicum Leaves Extract on Rats with Induced Diabetes Mellitus |
| title_full | Hypolipidemic Effects of Eryngium Caucasicum Leaves Extract on Rats with Induced Diabetes Mellitus |
| title_fullStr | Hypolipidemic Effects of Eryngium Caucasicum Leaves Extract on Rats with Induced Diabetes Mellitus |
| title_full_unstemmed | Hypolipidemic Effects of Eryngium Caucasicum Leaves Extract on Rats with Induced Diabetes Mellitus |
| title_short | Hypolipidemic Effects of Eryngium Caucasicum Leaves Extract on Rats with Induced Diabetes Mellitus |
| title_sort | hypolipidemic effects of eryngium caucasicum leaves extract on rats with induced diabetes mellitus |
| topic | eryngium caucasicum stz diabetes liver function and hypolipidemia |
| url | https://www.anbarjvs.edu.iq/?mno=206916 |
| work_keys_str_mv | AT glauciodirefeliciano hypolipidemiceffectsoferyngiumcaucasicumleavesextractonratswithinduceddiabetesmellitus |