Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis
Abstract Objective Cortical atrophy close to medial temporal structures has been described consistently in patients with temporal lobe epilepsy (TLE). Successful TLE surgery may have a neuroprotective effect preventing further atrophy of temporal and extratemporal cortex. However, the effects of epi...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Epilepsia Open |
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| Online Access: | https://doi.org/10.1002/epi4.13088 |
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| author | Aleksa Pejovic Zorica Jokovic Matthias Koepp Marko Dakovic Vladimir Bascarevic Marija Jovanovic Nikola Vojvodic Dragoslav Sokic Aleksandar J. Ristic |
| author_facet | Aleksa Pejovic Zorica Jokovic Matthias Koepp Marko Dakovic Vladimir Bascarevic Marija Jovanovic Nikola Vojvodic Dragoslav Sokic Aleksandar J. Ristic |
| author_sort | Aleksa Pejovic |
| collection | DOAJ |
| description | Abstract Objective Cortical atrophy close to medial temporal structures has been described consistently in patients with temporal lobe epilepsy (TLE). Successful TLE surgery may have a neuroprotective effect preventing further atrophy of temporal and extratemporal cortex. However, the effects of epilepsy surgery on subcortical structures demand additional enlightenment. This work aimed to determine how epilepsy surgery affects volumes of subcortical structures in medically refractory temporal lobe epilepsy patients. Methods We compared MRI volumes of subcortical structures in 62 patients with TLE (36 left, 26 right) before and after anterior temporal lobectomy with 38 TLE patients (20 left, 18 right) who were considered to be good surgical candidates and had at least two brain MRIs. Results There were no volume differences in subcortical structures on preoperative and initial MRIs of non‐operated TLE patients. At baseline, the ipsilateral thalamus and putamen in TLE patients were marginally smaller than contralateral structures. Operated patients showed a significant postoperative volume reduction in ipsilateral thalamus, putamen, and globus pallidus. In contrast, there were no significant volumetric reductions in non‐operated patients longitudinally. There were no volumetric changes associated with different surgical outcomes or different postoperative cognitive outcomes. Significance Our study demonstrated postoperative volume loss of thalamus, putamen and globus pallidus ipsilaterally to the side of resection. Our findings suggest surgery‐related changes, likely Wallerian degeneration within subcortical networks not related to seizure or cognitive outcome. Plain Language Summary We studied 100 patients with epilepsy, comparing those who had surgery to those who did not. After surgery, the thalamus, putamen and globus pallidus on the same side as the surgery shrank significantly, but not in non‐surgery patients. This suggests surgery‐related changes in deeper brain structures, unrelated to seizure freedom or cognitive outcomes. This research sheds additional light on the response of the subcortical structure to epilepsy surgery, highlighting potential areas for further study. |
| format | Article |
| id | doaj-art-70a5f1c6c34e4c7790108c809d93c47a |
| institution | Kabale University |
| issn | 2470-9239 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Epilepsia Open |
| spelling | doaj-art-70a5f1c6c34e4c7790108c809d93c47a2024-12-11T17:10:11ZengWileyEpilepsia Open2470-92392024-12-01962479248610.1002/epi4.13088Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysisAleksa Pejovic0Zorica Jokovic1Matthias Koepp2Marko Dakovic3Vladimir Bascarevic4Marija Jovanovic5Nikola Vojvodic6Dragoslav Sokic7Aleksandar J. Ristic8Clinic for Neurology University Clinical Center of Serbia Belgrade SerbiaFaculty of Medicine University of Belgrade Belgrade SerbiaInstitute of Neurology University College London London UKFaculty of Physical Chemistry University of Belgrade Belgrade SerbiaFaculty of Medicine University of Belgrade Belgrade SerbiaRadiology and Magnetic Resonance Imaging Center University Clinical Center of Serbia Belgrade SerbiaClinic for Neurology University Clinical Center of Serbia Belgrade SerbiaClinic for Neurology University Clinical Center of Serbia Belgrade SerbiaClinic for Neurology University Clinical Center of Serbia Belgrade SerbiaAbstract Objective Cortical atrophy close to medial temporal structures has been described consistently in patients with temporal lobe epilepsy (TLE). Successful TLE surgery may have a neuroprotective effect preventing further atrophy of temporal and extratemporal cortex. However, the effects of epilepsy surgery on subcortical structures demand additional enlightenment. This work aimed to determine how epilepsy surgery affects volumes of subcortical structures in medically refractory temporal lobe epilepsy patients. Methods We compared MRI volumes of subcortical structures in 62 patients with TLE (36 left, 26 right) before and after anterior temporal lobectomy with 38 TLE patients (20 left, 18 right) who were considered to be good surgical candidates and had at least two brain MRIs. Results There were no volume differences in subcortical structures on preoperative and initial MRIs of non‐operated TLE patients. At baseline, the ipsilateral thalamus and putamen in TLE patients were marginally smaller than contralateral structures. Operated patients showed a significant postoperative volume reduction in ipsilateral thalamus, putamen, and globus pallidus. In contrast, there were no significant volumetric reductions in non‐operated patients longitudinally. There were no volumetric changes associated with different surgical outcomes or different postoperative cognitive outcomes. Significance Our study demonstrated postoperative volume loss of thalamus, putamen and globus pallidus ipsilaterally to the side of resection. Our findings suggest surgery‐related changes, likely Wallerian degeneration within subcortical networks not related to seizure or cognitive outcome. Plain Language Summary We studied 100 patients with epilepsy, comparing those who had surgery to those who did not. After surgery, the thalamus, putamen and globus pallidus on the same side as the surgery shrank significantly, but not in non‐surgery patients. This suggests surgery‐related changes in deeper brain structures, unrelated to seizure freedom or cognitive outcomes. This research sheds additional light on the response of the subcortical structure to epilepsy surgery, highlighting potential areas for further study.https://doi.org/10.1002/epi4.13088epilepsy surgerysubcortical structurestemporal lobe epilepsyvolumetric analysis |
| spellingShingle | Aleksa Pejovic Zorica Jokovic Matthias Koepp Marko Dakovic Vladimir Bascarevic Marija Jovanovic Nikola Vojvodic Dragoslav Sokic Aleksandar J. Ristic Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis Epilepsia Open epilepsy surgery subcortical structures temporal lobe epilepsy volumetric analysis |
| title | Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis |
| title_full | Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis |
| title_fullStr | Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis |
| title_full_unstemmed | Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis |
| title_short | Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis |
| title_sort | progressive postoperative atrophy of ipsilateral thalamus putamen and globus pallidus in patients with temporal lobe epilepsy a volumetric analysis |
| topic | epilepsy surgery subcortical structures temporal lobe epilepsy volumetric analysis |
| url | https://doi.org/10.1002/epi4.13088 |
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