Characterization and determination of prevalence in autoimmune liver diseases in a tertiary center.
Introduction and Objectives: Autoimmune Hepatic Diseases (AHD) involve a chronic immunomediated response towards hepatocytes and bile ducts, as seen in Primary Biliary Cholangitis (PBC), Autoimmune Hepatitis (AIH), and Primary Sclerosing Cholangitis (PSC). Their complex diagnosis, lack of studies, a...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-04-01
|
| Series: | Annals of Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268125001036 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849315528794963968 |
|---|---|
| author | Ernesto J. Medina-Avalos Gabriela Rangel-Zavala Jose L. Pérez-Hernández Viridiana López-Ladrón de Guevara Fátima Higuera-De la Tijera |
| author_facet | Ernesto J. Medina-Avalos Gabriela Rangel-Zavala Jose L. Pérez-Hernández Viridiana López-Ladrón de Guevara Fátima Higuera-De la Tijera |
| author_sort | Ernesto J. Medina-Avalos |
| collection | DOAJ |
| description | Introduction and Objectives: Autoimmune Hepatic Diseases (AHD) involve a chronic immunomediated response towards hepatocytes and bile ducts, as seen in Primary Biliary Cholangitis (PBC), Autoimmune Hepatitis (AIH), and Primary Sclerosing Cholangitis (PSC). Their complex diagnosis, lack of studies, and irreversible liver damage pose significant challenges today due to increased mortality. Materials and Patients: A retrospective (cross-sectional, retrolective) study was conducted. Patient records from men and women aged 18 and above attending the Liver Clinic from 2020 to 2023 were analyzed. Data included demographic, clinical, biochemical, serological, and histological variables compatible with EHAI diagnosis. Descriptive statistics such as frequency, percentages, measures of central tendency, and dispersion were employed for qualitative and quantitative variables. Results: The prevalence of AHD during the evaluated period was 11.5% in our population. A total of 201 patients were identified, comprising 85 (42%) with PBC, 65 (32%) with AIH, 7 (4%) with PSC, and 44 (22%) with overlap (Figure 1). Among them, 177 (88%) were female. The mean age at diagnosis was 51 years ± 13.2. 28% had associated autoimmune diseases, with thyroid disease being the most common at 33%. Hepatic cirrhosis was the most frequent presentation (60%) at diagnosis, with 60% exhibiting decompensation (64% with variceal digestive bleeding) (Figure 2). PBC accounted for 47% of cirrhosis cases. Liver transplantation was performed in 6% of EHAI cases, mainly due to AIH. Conclusions: The diagnosis of AHD shows a progressive increase. A high incidence of advanced stages of liver disease related to AHD is observed. Further research is needed to define the prevalence and characterize these patients, thus enhancing early and effective diagnosis. |
| format | Article |
| id | doaj-art-70a4039fd02f42f5be7cf64ce3399b6f |
| institution | Kabale University |
| issn | 1665-2681 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj-art-70a4039fd02f42f5be7cf64ce3399b6f2025-08-20T03:52:07ZengElsevierAnnals of Hepatology1665-26812025-04-013010187910.1016/j.aohep.2025.101879Characterization and determination of prevalence in autoimmune liver diseases in a tertiary center.Ernesto J. Medina-Avalos0Gabriela Rangel-Zavala1Jose L. Pérez-Hernández2Viridiana López-Ladrón de Guevara3Fátima Higuera-De la Tijera4Department of Gastroenterology and Hepatology, General Hospital of México Dr. Eduardo Liceaga, MexicoDepartment of Gastroenterology and Hepatology, General Hospital of México Dr. Eduardo Liceaga, MexicoDepartment of Gastroenterology and Hepatology, General Hospital of México Dr. Eduardo Liceaga, MexicoDepartment of Gastroenterology and Hepatology, General Hospital of México Dr. Eduardo Liceaga, MexicoDepartment of Gastroenterology and Hepatology, General Hospital of México Dr. Eduardo Liceaga, MexicoIntroduction and Objectives: Autoimmune Hepatic Diseases (AHD) involve a chronic immunomediated response towards hepatocytes and bile ducts, as seen in Primary Biliary Cholangitis (PBC), Autoimmune Hepatitis (AIH), and Primary Sclerosing Cholangitis (PSC). Their complex diagnosis, lack of studies, and irreversible liver damage pose significant challenges today due to increased mortality. Materials and Patients: A retrospective (cross-sectional, retrolective) study was conducted. Patient records from men and women aged 18 and above attending the Liver Clinic from 2020 to 2023 were analyzed. Data included demographic, clinical, biochemical, serological, and histological variables compatible with EHAI diagnosis. Descriptive statistics such as frequency, percentages, measures of central tendency, and dispersion were employed for qualitative and quantitative variables. Results: The prevalence of AHD during the evaluated period was 11.5% in our population. A total of 201 patients were identified, comprising 85 (42%) with PBC, 65 (32%) with AIH, 7 (4%) with PSC, and 44 (22%) with overlap (Figure 1). Among them, 177 (88%) were female. The mean age at diagnosis was 51 years ± 13.2. 28% had associated autoimmune diseases, with thyroid disease being the most common at 33%. Hepatic cirrhosis was the most frequent presentation (60%) at diagnosis, with 60% exhibiting decompensation (64% with variceal digestive bleeding) (Figure 2). PBC accounted for 47% of cirrhosis cases. Liver transplantation was performed in 6% of EHAI cases, mainly due to AIH. Conclusions: The diagnosis of AHD shows a progressive increase. A high incidence of advanced stages of liver disease related to AHD is observed. Further research is needed to define the prevalence and characterize these patients, thus enhancing early and effective diagnosis.http://www.sciencedirect.com/science/article/pii/S1665268125001036 |
| spellingShingle | Ernesto J. Medina-Avalos Gabriela Rangel-Zavala Jose L. Pérez-Hernández Viridiana López-Ladrón de Guevara Fátima Higuera-De la Tijera Characterization and determination of prevalence in autoimmune liver diseases in a tertiary center. Annals of Hepatology |
| title | Characterization and determination of prevalence in autoimmune liver diseases in a tertiary center. |
| title_full | Characterization and determination of prevalence in autoimmune liver diseases in a tertiary center. |
| title_fullStr | Characterization and determination of prevalence in autoimmune liver diseases in a tertiary center. |
| title_full_unstemmed | Characterization and determination of prevalence in autoimmune liver diseases in a tertiary center. |
| title_short | Characterization and determination of prevalence in autoimmune liver diseases in a tertiary center. |
| title_sort | characterization and determination of prevalence in autoimmune liver diseases in a tertiary center |
| url | http://www.sciencedirect.com/science/article/pii/S1665268125001036 |
| work_keys_str_mv | AT ernestojmedinaavalos characterizationanddeterminationofprevalenceinautoimmuneliverdiseasesinatertiarycenter AT gabrielarangelzavala characterizationanddeterminationofprevalenceinautoimmuneliverdiseasesinatertiarycenter AT joselperezhernandez characterizationanddeterminationofprevalenceinautoimmuneliverdiseasesinatertiarycenter AT viridianalopezladrondeguevara characterizationanddeterminationofprevalenceinautoimmuneliverdiseasesinatertiarycenter AT fatimahigueradelatijera characterizationanddeterminationofprevalenceinautoimmuneliverdiseasesinatertiarycenter |