Direct and indirect salt effects on homotypic phase separation

Direct and indirect salt effects on homotypic phase separation

The low-complexity domain of hnRNPA1 (A1-LCD) phase separates in a salt-dependent manner. Unlike many intrinsically disordered proteins (IDPs) whose phase separation is suppressed by increasing salt concentrations, the phase separation of A1-LCD is promoted by >100 mM NaCl. To investigate the...

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Bibliographic Details
Main Authors: Matt MacAinsh, Souvik Dey, Huan-Xiang Zhou
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
phase separation
salt effects
salt dependence
molecular dynamics simulations
Online Access:https://elifesciences.org/articles/100282
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