Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect
Background: The rise of drug-resistant bacteria, including Staphylococcus aureus and Escherichia coli, presents a significant healthcare challenge. This study focuses on the development of two novel nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated within a biocompatible poly(VCL-co-PEGDA) h...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Electronic Journal of Biotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0717345824000277 |
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| author | Coralia Cuadrado Alex Mantilla Luis Hidalgo Diego Punina |
| author_facet | Coralia Cuadrado Alex Mantilla Luis Hidalgo Diego Punina |
| author_sort | Coralia Cuadrado |
| collection | DOAJ |
| description | Background: The rise of drug-resistant bacteria, including Staphylococcus aureus and Escherichia coli, presents a significant healthcare challenge. This study focuses on the development of two novel nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated within a biocompatible poly(VCL-co-PEGDA) hydrogel. These composites are designed for use in photodynamic therapy and evaluated for their antimicrobial efficacy against resistant pathogens. Results: The synthesized nanocomposites, when irradiated with red light at 630 nm, showed significant antimicrobial activity, resulting in a marked reduction in the viability of S. aureus ATCC 27543, S. aureus ATCC 33591, and E. coli ATCC 971182. Photodynamic studies demonstrated that the IONs-GO-Pc nanocomposite was more efficient in generating singlet oxygen compared to IONs-MWCNTs-Pc, which correlated with its superior antimicrobial performance. Structural and chemical characterization confirmed the successful incorporation of nanomaterials and photosensitizers, enhancing the photodynamic effect. Conclusions: The study demonstrates that both IONs-MWCNTs-Pc and IONs-GO-Pc nanocomposites show promise as alternative treatments for infections caused by antibiotic-resistant bacteria, with the GO-based composite showing higher photodynamic therapy efficacy. These findings suggest that such nanocomposites could play a pivotal role in advancing antimicrobial strategies against resistant pathogens.How to cite: Cuadrado C, Mantilla A, Hidalgo L, et al. Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect. Electron J Biotechnol 2025;73. https://doi.org/10.1016/j.ejbt.2024.08.002. |
| format | Article |
| id | doaj-art-707f9a57dc0c4929815116d666bd85a4 |
| institution | Kabale University |
| issn | 0717-3458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Electronic Journal of Biotechnology |
| spelling | doaj-art-707f9a57dc0c4929815116d666bd85a42025-01-11T06:38:27ZengElsevierElectronic Journal of Biotechnology0717-34582025-01-01731831Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effectCoralia Cuadrado0Alex Mantilla1Luis Hidalgo2Diego Punina3Facultad de Mecánica, Escuela Superior Politécnica de Chimborazo, Panamericana Sur km 1 1/2, Riobamba, 060155, Ecuador; Corresponding author.Facultad de Administración de Empresas, Escuela Superior Politécnica de Chimborazo, Panamericana Sur km 1 1/2, Riobamba, 060155, EcuadorFacultad de Mecánica, Escuela Superior Politécnica de Chimborazo, Panamericana Sur km 1 1/2, Riobamba, 060155, EcuadorFacultad de Mecánica, Escuela Superior Politécnica de Chimborazo, Panamericana Sur km 1 1/2, Riobamba, 060155, EcuadorBackground: The rise of drug-resistant bacteria, including Staphylococcus aureus and Escherichia coli, presents a significant healthcare challenge. This study focuses on the development of two novel nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated within a biocompatible poly(VCL-co-PEGDA) hydrogel. These composites are designed for use in photodynamic therapy and evaluated for their antimicrobial efficacy against resistant pathogens. Results: The synthesized nanocomposites, when irradiated with red light at 630 nm, showed significant antimicrobial activity, resulting in a marked reduction in the viability of S. aureus ATCC 27543, S. aureus ATCC 33591, and E. coli ATCC 971182. Photodynamic studies demonstrated that the IONs-GO-Pc nanocomposite was more efficient in generating singlet oxygen compared to IONs-MWCNTs-Pc, which correlated with its superior antimicrobial performance. Structural and chemical characterization confirmed the successful incorporation of nanomaterials and photosensitizers, enhancing the photodynamic effect. Conclusions: The study demonstrates that both IONs-MWCNTs-Pc and IONs-GO-Pc nanocomposites show promise as alternative treatments for infections caused by antibiotic-resistant bacteria, with the GO-based composite showing higher photodynamic therapy efficacy. These findings suggest that such nanocomposites could play a pivotal role in advancing antimicrobial strategies against resistant pathogens.How to cite: Cuadrado C, Mantilla A, Hidalgo L, et al. Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect. Electron J Biotechnol 2025;73. https://doi.org/10.1016/j.ejbt.2024.08.002.http://www.sciencedirect.com/science/article/pii/S0717345824000277Antibiotic evaluationAntibiotic-resistant bacteriaAntimicrobialBiocompatible hydrogel matrixCarbon nanotubesGraphene oxide |
| spellingShingle | Coralia Cuadrado Alex Mantilla Luis Hidalgo Diego Punina Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect Electronic Journal of Biotechnology Antibiotic evaluation Antibiotic-resistant bacteria Antimicrobial Biocompatible hydrogel matrix Carbon nanotubes Graphene oxide |
| title | Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect |
| title_full | Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect |
| title_fullStr | Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect |
| title_full_unstemmed | Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect |
| title_short | Antibiotic evaluation of the nanocomposites IONs-MWCNTs-Pc and IONs-GO-Pc encapsulated in the biocompatible hydrogel poly(VCL-co-PEGDA) based on photodynamic effect |
| title_sort | antibiotic evaluation of the nanocomposites ions mwcnts pc and ions go pc encapsulated in the biocompatible hydrogel poly vcl co pegda based on photodynamic effect |
| topic | Antibiotic evaluation Antibiotic-resistant bacteria Antimicrobial Biocompatible hydrogel matrix Carbon nanotubes Graphene oxide |
| url | http://www.sciencedirect.com/science/article/pii/S0717345824000277 |
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