Endothelium-derived 6-nitrodopamine is the major mechanism by which nitric oxide relaxes the rabbit isolated aorta

Endothelium-derived 6-nitrodopamine is the major mechanism by which nitric oxide relaxes the rabbit isolated aorta

6-Nitrodopamine (6-ND) is the predominant catecholamine released from isolated vascular tissues in both mammals and reptiles, with its release being significantly reduced by the NO synthesis inhibitor, Nω-nitro-L-arginine methyl ester (L-NAME). The vasorelaxation induced by 6-ND is unaffected by eit...

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Main Authors: Eric Xavier Dos Santos, José Britto-Júnior, João Victor Ribeiro, Gilberto Quirino Junior, Antonio Tiago Lima, Manoel Odorico Moraes, Maria Elisabete A. Moraes, Edson Antunes, André Schenka, Gilberto De Nucci
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
indomethacin
cyclo-oxygenase
cyclic GMP
acetylcholine
endothelium-dependent hyperpolarization factor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1507802/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1507802/full

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