Retrospective Analysis of the Factors Affecting Recurrence, Survival, and Effect of Hippocampus Radiotherapy Doses on Neurocognitive Functions in Patients Diagnosed with Glioblastoma Multiforme
Objective: This study aimed to evaluate radiotherapy (RT) doses, RT effects on neurocognitive functions, and possible factors that may affect recurrence or death in patients with glioblastoma multiforme (GBM). Methods: The data of 21 patients with GBM were retrospectively analyzed. RT treatment pla...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2024-04-01
|
| Series: | Gazi Medical Journal |
| Subjects: | |
| Online Access: | https://gazimedj.com/articles/retrospective-analysis-of-the-factors-affecting-recurrence-survival-and-effect-of-hippocampus-radiotherapy-doses-on-neurocognitive-functions-in-patients-diagnosed-with-glioblastoma-multiforme/doi/gmj.2023.3762 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841525545431465984 |
|---|---|
| author | Sevilcan İnan Öznur Dönmez Tutanç Hülya Ertaş Fatih Aydemir Burcu Caner Turgay Toksoy Pınar Çona |
| author_facet | Sevilcan İnan Öznur Dönmez Tutanç Hülya Ertaş Fatih Aydemir Burcu Caner Turgay Toksoy Pınar Çona |
| author_sort | Sevilcan İnan |
| collection | DOAJ |
| description | Objective: This study aimed to evaluate radiotherapy (RT) doses, RT effects on neurocognitive functions, and possible factors that may affect recurrence or death in patients with glioblastoma multiforme (GBM).
Methods: The data of 21 patients with GBM were retrospectively analyzed. RT treatment plans and doses and hippocampus ipsilateral and contralateral doses were recorded. The Mini-Mental State Examination (MMSE) is used to assess neurocognitive functions. The time of recurrence and death, if any, of the patients was recorded. Factors such as gender, age, patient performance status, tumor size, tumor localization, type of surgery, and time between surgery and RT were analyzed to determine any effect on the risk of recurrence or death.
Results: The median planning target volume dose was 59.86 gray (Gy). The maximum ipsilateral hippocampus dose was 51.85 Gy, and the maximum contralateral hippocampus dose was 46.25 Gy. With the MMSE, 3 of 4 patients had cognitive impairment. At the end of follow-up, 16 patients had recurrence and died. The median disease-free survival was 10 months [95% confidence interval (CI): 5.7-14.2], and the median overall survival was 24 months (95% CI: 16.0-31.9). Only poor performance status increased the risk of recurrence (hazard ratio: 4.31, 95% CI: 1.26-14.70, p=0.02).
Conclusion: Because hippocampus shielding was not performed, our hippocampus doses were high. Hippocampal-sparing RT is essential for the preservation of neurocognitive functions. The increased risk of recurrence in patients with poor performance status is possibly related to treatment dose reduction, delay, or discontinuation. |
| format | Article |
| id | doaj-art-70543abc3a8c4f34838eba84338b2b82 |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-70543abc3a8c4f34838eba84338b2b822025-01-17T10:30:07ZengGalenos Publishing HouseGazi Medical Journal2147-20922024-04-0135216116710.12996/gmj.2023.3762Retrospective Analysis of the Factors Affecting Recurrence, Survival, and Effect of Hippocampus Radiotherapy Doses on Neurocognitive Functions in Patients Diagnosed with Glioblastoma MultiformeSevilcan İnan0https://orcid.org/0000-0003-0857-9988Öznur Dönmez Tutanç1https://orcid.org/0000-0002-7154-1934Hülya Ertaş2https://orcid.org/0000-0002-5872-8825Fatih Aydemir3https://orcid.org/0000-0002-3400-9025Burcu Caner4https://orcid.org/0000-0003-1591-3323Turgay Toksoy5https://orcid.org/0000-0002-9747-9016Pınar Çona6https://orcid.org/0000-0002-5504-9763University of Health Sciences Türkiye, Bursa City Hospital, Clinic of Radiation Oncology, Bursa, TürkiyeUniversity of Health Sciences Türkiye, Bursa City Hospital, Clinic of Radiation Oncology, Bursa, TürkiyeUniversity of Health Sciences Türkiye, Bursa City Hospital, Clinic of Medical Oncology, Bursa, TürkiyeUniversity of Health Sciences Türkiye, Bursa City Hospital, Clinic of Neurosurgery, Bursa, TürkiyeBursa Uludağ University Faculty of Medicine, Department of Medical Oncology, Bursa, TürkiyeAli Osman Sönmez Oncology Hospital, Clinic of Medical Physics, Bursa, TürkiyeUniversity of Health Sciences Türkiye, Bursa City Hospital, Medical Physics, Clinic of Radiation Oncology, Bursa, TürkiyeObjective: This study aimed to evaluate radiotherapy (RT) doses, RT effects on neurocognitive functions, and possible factors that may affect recurrence or death in patients with glioblastoma multiforme (GBM). Methods: The data of 21 patients with GBM were retrospectively analyzed. RT treatment plans and doses and hippocampus ipsilateral and contralateral doses were recorded. The Mini-Mental State Examination (MMSE) is used to assess neurocognitive functions. The time of recurrence and death, if any, of the patients was recorded. Factors such as gender, age, patient performance status, tumor size, tumor localization, type of surgery, and time between surgery and RT were analyzed to determine any effect on the risk of recurrence or death. Results: The median planning target volume dose was 59.86 gray (Gy). The maximum ipsilateral hippocampus dose was 51.85 Gy, and the maximum contralateral hippocampus dose was 46.25 Gy. With the MMSE, 3 of 4 patients had cognitive impairment. At the end of follow-up, 16 patients had recurrence and died. The median disease-free survival was 10 months [95% confidence interval (CI): 5.7-14.2], and the median overall survival was 24 months (95% CI: 16.0-31.9). Only poor performance status increased the risk of recurrence (hazard ratio: 4.31, 95% CI: 1.26-14.70, p=0.02). Conclusion: Because hippocampus shielding was not performed, our hippocampus doses were high. Hippocampal-sparing RT is essential for the preservation of neurocognitive functions. The increased risk of recurrence in patients with poor performance status is possibly related to treatment dose reduction, delay, or discontinuation.https://gazimedj.com/articles/retrospective-analysis-of-the-factors-affecting-recurrence-survival-and-effect-of-hippocampus-radiotherapy-doses-on-neurocognitive-functions-in-patients-diagnosed-with-glioblastoma-multiforme/doi/gmj.2023.3762glioblastomaradiotherapyhippocampuscognitive dysfunction |
| spellingShingle | Sevilcan İnan Öznur Dönmez Tutanç Hülya Ertaş Fatih Aydemir Burcu Caner Turgay Toksoy Pınar Çona Retrospective Analysis of the Factors Affecting Recurrence, Survival, and Effect of Hippocampus Radiotherapy Doses on Neurocognitive Functions in Patients Diagnosed with Glioblastoma Multiforme Gazi Medical Journal glioblastoma radiotherapy hippocampus cognitive dysfunction |
| title | Retrospective Analysis of the Factors Affecting Recurrence, Survival, and Effect of Hippocampus Radiotherapy Doses on Neurocognitive Functions in Patients Diagnosed with Glioblastoma Multiforme |
| title_full | Retrospective Analysis of the Factors Affecting Recurrence, Survival, and Effect of Hippocampus Radiotherapy Doses on Neurocognitive Functions in Patients Diagnosed with Glioblastoma Multiforme |
| title_fullStr | Retrospective Analysis of the Factors Affecting Recurrence, Survival, and Effect of Hippocampus Radiotherapy Doses on Neurocognitive Functions in Patients Diagnosed with Glioblastoma Multiforme |
| title_full_unstemmed | Retrospective Analysis of the Factors Affecting Recurrence, Survival, and Effect of Hippocampus Radiotherapy Doses on Neurocognitive Functions in Patients Diagnosed with Glioblastoma Multiforme |
| title_short | Retrospective Analysis of the Factors Affecting Recurrence, Survival, and Effect of Hippocampus Radiotherapy Doses on Neurocognitive Functions in Patients Diagnosed with Glioblastoma Multiforme |
| title_sort | retrospective analysis of the factors affecting recurrence survival and effect of hippocampus radiotherapy doses on neurocognitive functions in patients diagnosed with glioblastoma multiforme |
| topic | glioblastoma radiotherapy hippocampus cognitive dysfunction |
| url | https://gazimedj.com/articles/retrospective-analysis-of-the-factors-affecting-recurrence-survival-and-effect-of-hippocampus-radiotherapy-doses-on-neurocognitive-functions-in-patients-diagnosed-with-glioblastoma-multiforme/doi/gmj.2023.3762 |
| work_keys_str_mv | AT sevilcaninan retrospectiveanalysisofthefactorsaffectingrecurrencesurvivalandeffectofhippocampusradiotherapydosesonneurocognitivefunctionsinpatientsdiagnosedwithglioblastomamultiforme AT oznurdonmeztutanc retrospectiveanalysisofthefactorsaffectingrecurrencesurvivalandeffectofhippocampusradiotherapydosesonneurocognitivefunctionsinpatientsdiagnosedwithglioblastomamultiforme AT hulyaertas retrospectiveanalysisofthefactorsaffectingrecurrencesurvivalandeffectofhippocampusradiotherapydosesonneurocognitivefunctionsinpatientsdiagnosedwithglioblastomamultiforme AT fatihaydemir retrospectiveanalysisofthefactorsaffectingrecurrencesurvivalandeffectofhippocampusradiotherapydosesonneurocognitivefunctionsinpatientsdiagnosedwithglioblastomamultiforme AT burcucaner retrospectiveanalysisofthefactorsaffectingrecurrencesurvivalandeffectofhippocampusradiotherapydosesonneurocognitivefunctionsinpatientsdiagnosedwithglioblastomamultiforme AT turgaytoksoy retrospectiveanalysisofthefactorsaffectingrecurrencesurvivalandeffectofhippocampusradiotherapydosesonneurocognitivefunctionsinpatientsdiagnosedwithglioblastomamultiforme AT pınarcona retrospectiveanalysisofthefactorsaffectingrecurrencesurvivalandeffectofhippocampusradiotherapydosesonneurocognitivefunctionsinpatientsdiagnosedwithglioblastomamultiforme |