Lipoprotein N-terminal modification in Bacillus: a new paradigm for extracellular acetylation and species-dependent Toll-like receptor 2 immunomodulation

Lipoprotein N-terminal modification in Bacillus: a new paradigm for extracellular acetylation and species-dependent Toll-like receptor 2 immunomodulation

ABSTRACT Lipoproteins are a defining feature of extracellular bacterial membrane surfaces. Acylation of an invariant N-terminal cysteine residue tethers proteins to the cell surface, where they participate in many cellular processes occurring at the membrane-environment interface. Lipoproteins also...

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Bibliographic Details
Main Authors: Gloria Komazin, Rachel M. Wigmore, Aditi M. Ranade, Amena A. Rizk, John H. Gardiner, Timothy C. Meredith
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
bacterial lipoproteins
acetyltransferase
Toll-like receptor 2
acylation
extracellular acetylation
Online Access:https://journals.asm.org/doi/10.1128/mbio.00996-25
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https://journals.asm.org/doi/10.1128/mbio.00996-25

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