Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion
Abstract Background Prostate cancer (PCa) is the leading cause of cancer-related morbidity and mortality in men worldwide. An early and accurate diagnosis is crucial for effective treatment and prognosis. Traditional invasive procedures such as image-guided prostate biopsy often cause discomfort and...
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BMC
2025-01-01
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| Series: | Cancer Imaging |
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| Online Access: | https://doi.org/10.1186/s40644-024-00819-z |
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| author | Xin Huang Huarong Ye Yugang Hu Yumeng Lei Yi Tian Xingyue Huang Jun Zhang Yao Zhang Bin Gui Qianhui Liu Ge Zhang Qing Deng |
| author_facet | Xin Huang Huarong Ye Yugang Hu Yumeng Lei Yi Tian Xingyue Huang Jun Zhang Yao Zhang Bin Gui Qianhui Liu Ge Zhang Qing Deng |
| author_sort | Xin Huang |
| collection | DOAJ |
| description | Abstract Background Prostate cancer (PCa) is the leading cause of cancer-related morbidity and mortality in men worldwide. An early and accurate diagnosis is crucial for effective treatment and prognosis. Traditional invasive procedures such as image-guided prostate biopsy often cause discomfort and complications, deterring some patients from undergoing these necessary tests. This study aimed to explore the feasibility and clinical value of using ultrasound super-resolution imaging (US SRI) for non-invasively assessing the microvessel characteristics of prostate lesion. Methods This study included 127 patients with prostate lesion who presented at Renmin Hospital of Wuhan University between November 2023 and June 2024 were included in this study. All the patients underwent transrectal US (TRUS), contrast-enhanced US (CEUS), and US SRI. CEUS parameters of time-intensity curve (TIC): arrival time (AT), rising time (RT), time to peak (TTP), peak intensity (PKI), falling time (FT), mean transit time (MTT), ascending slope (AS), descending slope (DS), D/A slope ratio (SR), and area under the TIC (AUC). US SRI parameters: microvessel density (MVD), microvessel diameter (D), microvessel velocity (V), microvessel tortuosity (T), and fractal number (FN), were analyzed and compared between prostate benign and malignant lesion. Results The tumor markers of prostate in the malignant group were all higher than those in the benign group, and the differences were statistically significant (P < 0.001). The TIC parameters of CEUS revealed that the PKI, AS, DS, and AUC were significantly higher in the malignant group than in the benign group (P < 0.001), whereas the RT, TTP and FT in the malignant group were significantly lower (P < 0.001). Malignant lesion exhibited significantly higher MVD, larger D, faster V, greater T, and more complex FN than benign lesion (P < 0.001). Conclusions US SRI is a promising non-invasive imaging modality that can provide detailed microvessel characteristics of prostate lesion, offering an advancement in the differential diagnosis for prostate lesion. And, US SRI may be a valuable tool in clinical practice with its ability to display and quantify microvessel with high precision. |
| format | Article |
| id | doaj-art-702be5d980ee4de9980652f76fbd0f3a |
| institution | Kabale University |
| issn | 1470-7330 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj-art-702be5d980ee4de9980652f76fbd0f3a2025-01-12T12:37:59ZengBMCCancer Imaging1470-73302025-01-012511910.1186/s40644-024-00819-zUltrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesionXin Huang0Huarong Ye1Yugang Hu2Yumeng Lei3Yi Tian4Xingyue Huang5Jun Zhang6Yao Zhang7Bin Gui8Qianhui Liu9Ge Zhang10Qing Deng11Department of Ultrasound Imaging, Renmin Hospital of Wuhan UniversityDepartment of Medical Ultrasound, China Resources & Wisco General Hospital, Wuhan University of Science and TechnologyDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan UniversityDepartment of Medical Ultrasound, China Resources & Wisco General Hospital, Wuhan University of Science and TechnologyDepartment of Medical Ultrasound, China Resources & Wisco General Hospital, Wuhan University of Science and TechnologyDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan UniversityDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan UniversityDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan UniversityDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan UniversityDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan UniversityDepartment of Medical Ultrasound, China Resources & Wisco General Hospital, Wuhan University of Science and TechnologyDepartment of Ultrasound Imaging, Renmin Hospital of Wuhan UniversityAbstract Background Prostate cancer (PCa) is the leading cause of cancer-related morbidity and mortality in men worldwide. An early and accurate diagnosis is crucial for effective treatment and prognosis. Traditional invasive procedures such as image-guided prostate biopsy often cause discomfort and complications, deterring some patients from undergoing these necessary tests. This study aimed to explore the feasibility and clinical value of using ultrasound super-resolution imaging (US SRI) for non-invasively assessing the microvessel characteristics of prostate lesion. Methods This study included 127 patients with prostate lesion who presented at Renmin Hospital of Wuhan University between November 2023 and June 2024 were included in this study. All the patients underwent transrectal US (TRUS), contrast-enhanced US (CEUS), and US SRI. CEUS parameters of time-intensity curve (TIC): arrival time (AT), rising time (RT), time to peak (TTP), peak intensity (PKI), falling time (FT), mean transit time (MTT), ascending slope (AS), descending slope (DS), D/A slope ratio (SR), and area under the TIC (AUC). US SRI parameters: microvessel density (MVD), microvessel diameter (D), microvessel velocity (V), microvessel tortuosity (T), and fractal number (FN), were analyzed and compared between prostate benign and malignant lesion. Results The tumor markers of prostate in the malignant group were all higher than those in the benign group, and the differences were statistically significant (P < 0.001). The TIC parameters of CEUS revealed that the PKI, AS, DS, and AUC were significantly higher in the malignant group than in the benign group (P < 0.001), whereas the RT, TTP and FT in the malignant group were significantly lower (P < 0.001). Malignant lesion exhibited significantly higher MVD, larger D, faster V, greater T, and more complex FN than benign lesion (P < 0.001). Conclusions US SRI is a promising non-invasive imaging modality that can provide detailed microvessel characteristics of prostate lesion, offering an advancement in the differential diagnosis for prostate lesion. And, US SRI may be a valuable tool in clinical practice with its ability to display and quantify microvessel with high precision.https://doi.org/10.1186/s40644-024-00819-zProstate lesionUltasound super-resolution imagingMicrovesselNon-invasive diagnosis |
| spellingShingle | Xin Huang Huarong Ye Yugang Hu Yumeng Lei Yi Tian Xingyue Huang Jun Zhang Yao Zhang Bin Gui Qianhui Liu Ge Zhang Qing Deng Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion Cancer Imaging Prostate lesion Ultasound super-resolution imaging Microvessel Non-invasive diagnosis |
| title | Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion |
| title_full | Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion |
| title_fullStr | Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion |
| title_full_unstemmed | Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion |
| title_short | Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion |
| title_sort | ultrasound super resolution imaging for non invasive assessment of microvessel in prostate lesion |
| topic | Prostate lesion Ultasound super-resolution imaging Microvessel Non-invasive diagnosis |
| url | https://doi.org/10.1186/s40644-024-00819-z |
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