Case Report: Dangerous liaisons between splenectomy and eltrombopag-induced chronic thromboembolic pulmonary hypertension in patients with immune thrombocytopenia: report of two cases and review of the literature

Case Report: Dangerous liaisons between splenectomy and eltrombopag-induced chronic thromboembolic pulmonary hypertension in patients with immune thrombocytopenia: report of two cases and review of the literature

IntroductionPrimary immune thrombocytopenia is an autoimmune bleeding disorder characterized by variable immune-mediated platelet destruction. These patients have reported thrombotic complications, both venous and arterial, in addition to bleeding. Splenectomy and thrombopoietin receptor agonists ar...

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Main Authors:	Roberto Castelli, Enrico Atzori, Alessandro Palmerio Delitala, Salvatore Antonio Masala, Valentina Micheluzzi, Enrico Ponti, Giuseppe Sanna, Dante Castro, Antonio Gidaro, Mattia Donadoni, Roberto Manetti, Pierluigi Merella, Nicia Isabella Profili, Andrea Maria D'Armini, Gavino Casu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	primary immune thrombocytopenia thrombopoietin receptors agonists eltrombopag splenectomy chronic thromboembolic pulmonary hypertension pulmonary thromboendarterectomy
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2025.1508574/full
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