Mitochondrial transplantation following cardiopulmonary resuscitation improves neurological function in rats by inducing M2-type MG/MΦ polarization

Mitochondrial transplantation following cardiopulmonary resuscitation improves neurological function in rats by inducing M2-type MG/MΦ polarization

Abstract Aim Explore the effects of mitochondrial transplantation (MT) after cardiopulmonary resuscitation (CPR) on the polarization of microglia/macrophages (MG/MΦ) and neurological function. Methods Seventy-five Sprague-Dawley rats were randomly divided into five groups: sham, normal saline (NS),...

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Bibliographic Details
Main Authors: Jie Zhu, Zhen Wang, Mengda Xu, Xuyuan Ma, Maozheng Shen, Jingyu Yan, Xiang Zhou
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Translational Medicine
Subjects:
Cardiac arrest
Mitochondrial transplantation
Neurological function
Microglia
Macrophages
Online Access:https://doi.org/10.1186/s12967-024-05815-2
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