Mendelian randomization analyses support causal relationships between gut microbiome and longevity
Abstract Background Gut microbiome plays a significant role in longevity, and dysbiosis is indeed one of the hallmarks of aging. However, the causal relationship between gut microbiota and human longevity or aging remains elusive. Methods Our study assessed the causal relationships between gut micro...
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BMC
2024-11-01
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| Series: | Journal of Translational Medicine |
| Online Access: | https://doi.org/10.1186/s12967-024-05823-2 |
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| author | Shu Chen Wei Chen Xudong Wang Sheng Liu |
| author_facet | Shu Chen Wei Chen Xudong Wang Sheng Liu |
| author_sort | Shu Chen |
| collection | DOAJ |
| description | Abstract Background Gut microbiome plays a significant role in longevity, and dysbiosis is indeed one of the hallmarks of aging. However, the causal relationship between gut microbiota and human longevity or aging remains elusive. Methods Our study assessed the causal relationships between gut microbiome and longevity using Mendelian Randomization (MR). Summary statistics for the gut microbiome were obtained from four genome-wide association study (GWAS) meta-analysis of the MiBioGen consortium (N = 18,340), Dutch Microbiome Project (N = 7738), German individuals (N = 8956), and Finland individuals (N = 5959). Summary statistics for Longevity were obtained from Five GWAS meta-analysis, including Human healthspan (N = 300,447), Longevity (N = 36,745), Lifespans (N = 1,012,240), Parental longevity (N = 389,166), and Frailty (one of the primary aging-linked physiological hallmarks, N = 175,226). Results Our findings reveal several noteworthy associations, including a negative correlation between Bacteroides massiliensis and longevity, whereas the genus Subdoligranulum and Alistipes, as well as species Alistipes senegalensis and Alistipes shahii, exhibited positive associations with specific longevity traits. Moreover, the microbial pathway of coenzyme A biosynthesis I, pyruvate fermentation to acetate and lactate II, and pentose phosphate pathway exhibited positive associations with two or more traits linked to longevity. Conversely, the TCA cycle VIII (helicobacter) pathway consistently demonstrated a negative correlation with lifespan and parental longevity. Conclusions Our findings of this MR study indicated many significant associations between gut microbiome and longevity. These microbial taxa and pathways may potentially play a protective role in promoting longevity or have a suppressive effect on lifespan. |
| format | Article |
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| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | Journal of Translational Medicine |
| spelling | doaj-art-6fe1fc8c909746ab9b1f26f0bb73ee2d2024-11-17T12:45:52ZengBMCJournal of Translational Medicine1479-58762024-11-0122111510.1186/s12967-024-05823-2Mendelian randomization analyses support causal relationships between gut microbiome and longevityShu Chen0Wei Chen1Xudong Wang2Sheng Liu3Department of Pathology, The Seven Affiliated Hospital, Sun Yat-Sen UniversityShenzhen Key Laboratory of Systems Medicine for Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen UniversityShenzhen Key Laboratory of Systems Medicine for Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen UniversityShenzhen Key Laboratory of Systems Medicine for Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen UniversityAbstract Background Gut microbiome plays a significant role in longevity, and dysbiosis is indeed one of the hallmarks of aging. However, the causal relationship between gut microbiota and human longevity or aging remains elusive. Methods Our study assessed the causal relationships between gut microbiome and longevity using Mendelian Randomization (MR). Summary statistics for the gut microbiome were obtained from four genome-wide association study (GWAS) meta-analysis of the MiBioGen consortium (N = 18,340), Dutch Microbiome Project (N = 7738), German individuals (N = 8956), and Finland individuals (N = 5959). Summary statistics for Longevity were obtained from Five GWAS meta-analysis, including Human healthspan (N = 300,447), Longevity (N = 36,745), Lifespans (N = 1,012,240), Parental longevity (N = 389,166), and Frailty (one of the primary aging-linked physiological hallmarks, N = 175,226). Results Our findings reveal several noteworthy associations, including a negative correlation between Bacteroides massiliensis and longevity, whereas the genus Subdoligranulum and Alistipes, as well as species Alistipes senegalensis and Alistipes shahii, exhibited positive associations with specific longevity traits. Moreover, the microbial pathway of coenzyme A biosynthesis I, pyruvate fermentation to acetate and lactate II, and pentose phosphate pathway exhibited positive associations with two or more traits linked to longevity. Conversely, the TCA cycle VIII (helicobacter) pathway consistently demonstrated a negative correlation with lifespan and parental longevity. Conclusions Our findings of this MR study indicated many significant associations between gut microbiome and longevity. These microbial taxa and pathways may potentially play a protective role in promoting longevity or have a suppressive effect on lifespan.https://doi.org/10.1186/s12967-024-05823-2 |
| spellingShingle | Shu Chen Wei Chen Xudong Wang Sheng Liu Mendelian randomization analyses support causal relationships between gut microbiome and longevity Journal of Translational Medicine |
| title | Mendelian randomization analyses support causal relationships between gut microbiome and longevity |
| title_full | Mendelian randomization analyses support causal relationships between gut microbiome and longevity |
| title_fullStr | Mendelian randomization analyses support causal relationships between gut microbiome and longevity |
| title_full_unstemmed | Mendelian randomization analyses support causal relationships between gut microbiome and longevity |
| title_short | Mendelian randomization analyses support causal relationships between gut microbiome and longevity |
| title_sort | mendelian randomization analyses support causal relationships between gut microbiome and longevity |
| url | https://doi.org/10.1186/s12967-024-05823-2 |
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