Restoration of miR-340 controls pancreatic cancer cell CD47 expression to promote macrophage phagocytosis and enhance antitumor immunity

Restoration of miR-340 controls pancreatic cancer cell CD47 expression to promote macrophage phagocytosis and enhance antitumor immunity

Background Immune checkpoint blockade has emerged as a potential cancer immunotherapy. The “don’t eat me” signal CD47 in cancer cells binds signal regulatory protein-α on macrophages and prevents their phagocytosis. The role of miR-340 in pancreatic ductal adenocarcinoma (PDAC), especially in tumor...

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Main Authors: Li Liu, Yan Li, Ying Chen, Qi Zhang, Lijuan Zhang, Chengzhi Wang, Qing Xi, Jieyou Zhang, Guangze Yang, Zimu Zhang, Xiangdong Guo, Jingyi Zhao, Zhenyi Xue, Yurong Da, Zhi Yao, Rongxin Zhang
Format: Article
Language:English
Published: BMJ Publishing Group 2020-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/1/e000253.full
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