Research advances in functional roles of Th17 and IL-17 in acute kidney injury
Acute kidney injury（AKI）is a clinical syndrome characterized by a rapid decline of renal function.Renal infiltrated immune cells and releases of inflammatory cytokines are key factors affecting the progression and outcome of AKI.Th17 cells and its inflammatory factors such as IL-17 are involved in i...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57902434&Fpath=home&index=0 |
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| _version_ | 1849323681429323776 |
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| author | Pang Hao-wen An Ning Yang Chen Liu Hua-feng |
| author_facet | Pang Hao-wen An Ning Yang Chen Liu Hua-feng |
| author_sort | Pang Hao-wen |
| collection | DOAJ |
| description | Acute kidney injury（AKI）is a clinical syndrome characterized by a rapid decline of renal function.Renal infiltrated immune cells and releases of inflammatory cytokines are key factors affecting the progression and outcome of AKI.Th17 cells and its inflammatory factors such as IL-17 are involved in immune regulation and mucosal defense and play key roles in autoimmune diseases.Recent studies have shown that Th17 cells and IL-17 not only affected the degree of kidney injury, but also modulated the recovery after AKI.This review summarized the latest research advances in the functional role of Th17 and IL-17 in AKI and discussed the therapeutic strategy by targeting Th17 cells and IL-17 in the treatment of AKI. |
| format | Article |
| id | doaj-art-6fb1ef9afcd44a228970e334a3bfec4a |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2021-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-6fb1ef9afcd44a228970e334a3bfec4a2025-08-20T03:48:58ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902021-01-012194495057902434Research advances in functional roles of Th17 and IL-17 in acute kidney injuryPang Hao-wenAn NingYang ChenLiu Hua-fengAcute kidney injury（AKI）is a clinical syndrome characterized by a rapid decline of renal function.Renal infiltrated immune cells and releases of inflammatory cytokines are key factors affecting the progression and outcome of AKI.Th17 cells and its inflammatory factors such as IL-17 are involved in immune regulation and mucosal defense and play key roles in autoimmune diseases.Recent studies have shown that Th17 cells and IL-17 not only affected the degree of kidney injury, but also modulated the recovery after AKI.This review summarized the latest research advances in the functional role of Th17 and IL-17 in AKI and discussed the therapeutic strategy by targeting Th17 cells and IL-17 in the treatment of AKI.http://www.lcszb.com/thesisDetails?columnId=57902434&Fpath=home&index=0Acute kidney injuryTh17 cellInterleukin-17NephritisRenal fibrosis |
| spellingShingle | Pang Hao-wen An Ning Yang Chen Liu Hua-feng Research advances in functional roles of Th17 and IL-17 in acute kidney injury Linchuang shenzangbing zazhi Acute kidney injury Th17 cell Interleukin-17 Nephritis Renal fibrosis |
| title | Research advances in functional roles of Th17 and IL-17 in acute kidney injury |
| title_full | Research advances in functional roles of Th17 and IL-17 in acute kidney injury |
| title_fullStr | Research advances in functional roles of Th17 and IL-17 in acute kidney injury |
| title_full_unstemmed | Research advances in functional roles of Th17 and IL-17 in acute kidney injury |
| title_short | Research advances in functional roles of Th17 and IL-17 in acute kidney injury |
| title_sort | research advances in functional roles of th17 and il 17 in acute kidney injury |
| topic | Acute kidney injury Th17 cell Interleukin-17 Nephritis Renal fibrosis |
| url | http://www.lcszb.com/thesisDetails?columnId=57902434&Fpath=home&index=0 |
| work_keys_str_mv | AT panghaowen researchadvancesinfunctionalrolesofth17andil17inacutekidneyinjury AT anning researchadvancesinfunctionalrolesofth17andil17inacutekidneyinjury AT yangchen researchadvancesinfunctionalrolesofth17andil17inacutekidneyinjury AT liuhuafeng researchadvancesinfunctionalrolesofth17andil17inacutekidneyinjury |