Lipocalin-2 promotes CKD vascular calcification by aggravating VSMCs ferroptosis through NCOA4/FTH1-mediated ferritinophagy

Lipocalin-2 promotes CKD vascular calcification by aggravating VSMCs ferroptosis through NCOA4/FTH1-mediated ferritinophagy

Abstract Vascular calcification (VC) is a common complication of chronic kidney disease (CKD), for which no effective therapies are available. Hyperphosphatemia, a feature of CKD, is a well-known inducer of VC. High phosphate (HP)-induced ferroptosis plays a crucial role in CKD-related VC (CKD-VC),...

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Bibliographic Details
Main Authors:	Yujia Wang, Yuxia Zhang, Min Gao, Zhiqing Chen, Jing Lu, Yongqi Li, Yan Di, Yinan Zhao, Bicheng Liu, Rining Tang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-11-01
Series:	Cell Death and Disease
Online Access:	https://doi.org/10.1038/s41419-024-07260-x
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