New Horizons in Cancer Progression and Metastasis: <i>Hippo</i> Signaling Pathway
The <i>Hippo</i> pathway is highly evolved to maintain tissue homeostasis in diverse species by regulating cell proliferation, differentiation, and apoptosis. In tumor biology, the <i>Hippo</i> pathway is a prime example of signaling molecules involved in cancer progression a...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/12/11/2552 |
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| Summary: | The <i>Hippo</i> pathway is highly evolved to maintain tissue homeostasis in diverse species by regulating cell proliferation, differentiation, and apoptosis. In tumor biology, the <i>Hippo</i> pathway is a prime example of signaling molecules involved in cancer progression and metastasis. <i>Hippo</i> core elements <i>LATS1, LATS2, MST1, YAP</i>, and <i>TAZ</i> have critical roles in the maintenance of traditional tissue architecture and cell homeostasis. However, in cancer development, dysregulation of <i>Hippo</i> signaling results in tumor progression and the formation secondary cancers. <i>Hippo</i> components not only transmit biochemical signals but also act as mediators of mechanotransduction pathways during malignant neoplasm development and metastatic disease. This review confers knowledge of <i>Hippo</i> pathway core components and their role in cancer progression and metastasis and highlights the clinical role of <i>Hippo</i> pathway in cancer treatment. The <i>Hippo</i> signaling pathway and its unresolved mechanisms hold great promise as potential therapeutic targets in the emerging field of metastatic cancer research. |
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| ISSN: | 2227-9059 |