Acute kidney injury in hematological patients treated with CAR-T cells: risk factors, clinical presentation and impact on outcomes

Acute kidney injury in hematological patients treated with CAR-T cells: risk factors, clinical presentation and impact on outcomes

Abstract Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematologic malignancies, yet it carries significant risks, including acute kidney injury (AKI). In this study, we investigated the risk factors and clinical impact of AKI in patients undergoing CAR-T cell...

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Bibliographic Details
Main Authors: Elisa Russo, Massimiliano Gambella, Anna Maria Raiola, Elena Beltrametti, Valentina Zanetti, Giuseppe Chirco, Francesca Viazzi, Emanuele Angelucci, Pasquale Esposito
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Acute kidney injury
Performance status
CAR-T cell therapy
Cytokine release syndrome
Disease-free survival
Mortality
Online Access:https://doi.org/10.1038/s41598-024-77720-z
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