Phytoconstituents, Antioxidant Activity and Cytotoxicity of <i>Puya chilensis</i> Mol. Extracts in Colon Cell Lines
<i>Puya chilensis</i> Mol. is a plant of the Bromeliaceae family, which has been traditionally used for medicinal applications in various digestive disorders. In this study, the phytoconstituents of six extracts of stems and flowers of <i>P. chilensis</i> were evaluated: phen...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
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| Series: | Plants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2223-7747/13/21/2989 |
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| Summary: | <i>Puya chilensis</i> Mol. is a plant of the Bromeliaceae family, which has been traditionally used for medicinal applications in various digestive disorders. In this study, the phytoconstituents of six extracts of stems and flowers of <i>P. chilensis</i> were evaluated: phenols, flavonoids and total anthraquinones, as well as their antioxidant capacity and cytotoxicity in colon cancer cell lines HT-29. The data demonstrate that the ethyl acetate extract of <i>P. chilensis</i> flowers is cytotoxic in HT-29 cell lines (IC<sub>50</sub> = 41.70 µg/mL) without causing toxic effects on healthy colon cells (IC<sub>50</sub> > 100 µg/mL); also, this extract concentrated the highest amount of phenols (4.63 μg GAE/g d.e.), flavonoids (31.5 μg QE/g d.e.) and anthraquinones (12.60 μg EE/g d.e.) among all the extracts tested, which also correlated with its highlighted antioxidant capacity (DPPH∙IC<sub>50</sub> = 4.15 mg/mL and FRAP 26.52 mM TEAC) over the other extracts. About thirty-five compounds were identified in this extract−the fatty acid esters present have been shown to have therapeutic effects on several types of cancer and could explain its antiproliferative activity. |
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| ISSN: | 2223-7747 |