Iron Deficiency in Patients with Left Ventricular Assist Devices
Iron deficiency is a common and independent predictor of adverse outcomes in patients with heart failure. The implications of iron deficiency in patients implanted with a left ventricular assist device (LVAD) are less established. This review recaps data on the prevalence, characteristics and impact...
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| Format: | Article |
| Language: | English |
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Radcliffe Medical Media
2024-07-01
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| Series: | Cardiac Failure Review |
| Online Access: | https://www.cfrjournal.com/articleindex/cfr.2023.26 |
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| _version_ | 1846122326583672832 |
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| author | William Herrik Nielsen Finn Gustafsson |
| author_facet | William Herrik Nielsen Finn Gustafsson |
| author_sort | William Herrik Nielsen |
| collection | DOAJ |
| description | Iron deficiency is a common and independent predictor of adverse outcomes in patients with heart failure. The implications of iron deficiency in patients implanted with a left ventricular assist device (LVAD) are less established. This review recaps data on the prevalence, characteristics and impact of Iron deficiency in the LVAD population. A systematic search yielded eight studies involving 517 LVAD patients, with iron deficiency prevalence ranging from 40% to 82%. IV iron repletion was not associated with adverse events and effectively resolved iron deficiency in most patients. However, the effects of iron deficiency and iron repletion on post-implant survival and exercise capacity remain unknown. Although iron deficiency is highly prevalent in LVAD patients, its true prevalence and adverse effects may be misestimated due to inexact diagnostic criteria. Future randomised controlled trials on IV iron treatment in LVAD patients are warranted to clarify the significance of this common comorbidity. |
| format | Article |
| id | doaj-art-6f70f1a61e744ae88a8d4eec9adb0326 |
| institution | Kabale University |
| issn | 2057-7540 2057-7559 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Cardiac Failure Review |
| spelling | doaj-art-6f70f1a61e744ae88a8d4eec9adb03262024-12-14T16:05:09ZengRadcliffe Medical MediaCardiac Failure Review2057-75402057-75592024-07-011010.15420/cfr.2023.26Iron Deficiency in Patients with Left Ventricular Assist DevicesWilliam Herrik Nielsen0Finn Gustafsson1Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkIron deficiency is a common and independent predictor of adverse outcomes in patients with heart failure. The implications of iron deficiency in patients implanted with a left ventricular assist device (LVAD) are less established. This review recaps data on the prevalence, characteristics and impact of Iron deficiency in the LVAD population. A systematic search yielded eight studies involving 517 LVAD patients, with iron deficiency prevalence ranging from 40% to 82%. IV iron repletion was not associated with adverse events and effectively resolved iron deficiency in most patients. However, the effects of iron deficiency and iron repletion on post-implant survival and exercise capacity remain unknown. Although iron deficiency is highly prevalent in LVAD patients, its true prevalence and adverse effects may be misestimated due to inexact diagnostic criteria. Future randomised controlled trials on IV iron treatment in LVAD patients are warranted to clarify the significance of this common comorbidity.https://www.cfrjournal.com/articleindex/cfr.2023.26 |
| spellingShingle | William Herrik Nielsen Finn Gustafsson Iron Deficiency in Patients with Left Ventricular Assist Devices Cardiac Failure Review |
| title | Iron Deficiency in Patients with Left Ventricular Assist Devices |
| title_full | Iron Deficiency in Patients with Left Ventricular Assist Devices |
| title_fullStr | Iron Deficiency in Patients with Left Ventricular Assist Devices |
| title_full_unstemmed | Iron Deficiency in Patients with Left Ventricular Assist Devices |
| title_short | Iron Deficiency in Patients with Left Ventricular Assist Devices |
| title_sort | iron deficiency in patients with left ventricular assist devices |
| url | https://www.cfrjournal.com/articleindex/cfr.2023.26 |
| work_keys_str_mv | AT williamherriknielsen irondeficiencyinpatientswithleftventricularassistdevices AT finngustafsson irondeficiencyinpatientswithleftventricularassistdevices |