Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway
Abstract Adult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling schistosomiasis. Here, we describe that Bantam mi...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07402-z |
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| author | Pengfei Du Tianqi Xia Xuxin Li Bikash R. Giri Chuantao Fang Shun Li Shi Yan Guofeng Cheng |
| author_facet | Pengfei Du Tianqi Xia Xuxin Li Bikash R. Giri Chuantao Fang Shun Li Shi Yan Guofeng Cheng |
| author_sort | Pengfei Du |
| collection | DOAJ |
| description | Abstract Adult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling schistosomiasis. Here, we describe that Bantam miRNA and miR-1989 regulate Wnt signaling pathway by targeting Frizzled-5/7/9, which is involved in ovarian development and oviposition. Additionally, Frizzled-7 could cooperate with SjRho to maintain normal ovarian development and egg productions and SjRho may interact with Hsp60 to potentially support Frizzled-7 trafficking and signaling. Further in vivo inhibition of SjRho in mice model infected with Schistosoma results in a remarkable decrease in worm burden and egg productions. Our findings not only broaden the functions of Bantam miRNA and miR-1989 as well as Wnt signaling pathway, but also imply that interruption of Bantam/miR-1989-Frizzled-5/7/9-SjRho axis may serve as effective targets against schistosomiasis. |
| format | Article |
| id | doaj-art-6f55560a831044de8e0a41e37685007e |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-6f55560a831044de8e0a41e37685007e2025-01-05T12:43:15ZengNature PortfolioCommunications Biology2399-36422024-12-017111410.1038/s42003-024-07402-zSchistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathwayPengfei Du0Tianqi Xia1Xuxin Li2Bikash R. Giri3Chuantao Fang4Shun Li5Shi Yan6Guofeng Cheng7Shanghai Tenth People’s Hospital, Institute for Infectious Diseases and Vaccine Development, School of Medicine, Tongji UniversityShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural AffairsShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural AffairsShanghai Tenth People’s Hospital, Institute for Infectious Diseases and Vaccine Development, School of Medicine, Tongji UniversityShanghai Tenth People’s Hospital, Institute for Infectious Diseases and Vaccine Development, School of Medicine, Tongji UniversityShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural AffairsInstitute of Parasitology, Department of Pathobiology, University of Veterinary Medicine ViennaShanghai Tenth People’s Hospital, Institute for Infectious Diseases and Vaccine Development, School of Medicine, Tongji UniversityAbstract Adult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling schistosomiasis. Here, we describe that Bantam miRNA and miR-1989 regulate Wnt signaling pathway by targeting Frizzled-5/7/9, which is involved in ovarian development and oviposition. Additionally, Frizzled-7 could cooperate with SjRho to maintain normal ovarian development and egg productions and SjRho may interact with Hsp60 to potentially support Frizzled-7 trafficking and signaling. Further in vivo inhibition of SjRho in mice model infected with Schistosoma results in a remarkable decrease in worm burden and egg productions. Our findings not only broaden the functions of Bantam miRNA and miR-1989 as well as Wnt signaling pathway, but also imply that interruption of Bantam/miR-1989-Frizzled-5/7/9-SjRho axis may serve as effective targets against schistosomiasis.https://doi.org/10.1038/s42003-024-07402-z |
| spellingShingle | Pengfei Du Tianqi Xia Xuxin Li Bikash R. Giri Chuantao Fang Shun Li Shi Yan Guofeng Cheng Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway Communications Biology |
| title | Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway |
| title_full | Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway |
| title_fullStr | Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway |
| title_full_unstemmed | Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway |
| title_short | Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway |
| title_sort | schistosoma sex biased micrornas regulate ovarian development and egg production by targeting wnt signaling pathway |
| url | https://doi.org/10.1038/s42003-024-07402-z |
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