Constructing the optimal experimental autoimmune thyroiditis mouse model using porcine thyroglobulin

Constructing the optimal experimental autoimmune thyroiditis mouse model using porcine thyroglobulin

IntroductionAutoimmune thyroiditis (AIT) is a chronic autoimmune disease characterized by lymphocytic infiltration of the thyroid gland and elevated specific antibodies. Its incidence rises annually, yet no standardized animal model fully mimics human AIT. Given unclear pathogenesis and lack of targ...

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Bibliographic Details
Main Authors:	Ke Liu, Pei Zhang, Zi-Shan Jin, Xiang-Kun Meng, Jin-Li Luo, Lin Han, Xiao-Tong Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Immunology
Subjects:	autoimmune thyroiditis experimental autoimmune thyroiditis NOD/LtJ mice animal model construction molecular mechanism
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1591196/full
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