Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review
Cancer immunotherapy—including immune checkpoint inhibition (ICI) and adoptive cell therapy (ACT)—has become a standard, potentially curative treatment for a subset of advanced solid and liquid tumors. However, most patients with cancer do not benefit from the rapidly evolving improvements in the un...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-01-01
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| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/13/1/e008876.full |
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| author | Francesco M Marincola Alessandra Cesano Yana G Najjar Davide Bedognetti Marco Ruella Sarah Warren Christine Spencer Elad Ziv Tomas Kirchhoff Jennifer McQuade Tullia C Bruno Jakob Nikolas Kather Allison Betof Warner Christian Hammer Alberto Carturan Ryan Augustin Rhine Shen Winson S Ho Rongze O Lu Luigi Barrea Violena Pietrobon Laura Soldati |
| author_facet | Francesco M Marincola Alessandra Cesano Yana G Najjar Davide Bedognetti Marco Ruella Sarah Warren Christine Spencer Elad Ziv Tomas Kirchhoff Jennifer McQuade Tullia C Bruno Jakob Nikolas Kather Allison Betof Warner Christian Hammer Alberto Carturan Ryan Augustin Rhine Shen Winson S Ho Rongze O Lu Luigi Barrea Violena Pietrobon Laura Soldati |
| author_sort | Francesco M Marincola |
| collection | DOAJ |
| description | Cancer immunotherapy—including immune checkpoint inhibition (ICI) and adoptive cell therapy (ACT)—has become a standard, potentially curative treatment for a subset of advanced solid and liquid tumors. However, most patients with cancer do not benefit from the rapidly evolving improvements in the understanding of principal mechanisms determining cancer immune responsiveness (CIR); including patient-specific genetically determined and acquired factors, as well as intrinsic cancer cell biology. Though CIR is multifactorial, fundamental concepts are emerging that should be considered for the design of novel therapeutic strategies and related clinical studies. Recent advancements as well as novel approaches to address the limitations of current treatments are discussed here, with a specific focus on ICI and ACT. |
| format | Article |
| id | doaj-art-6f1eb72d38eb4e598180d487f6164a8f |
| institution | Kabale University |
| issn | 2051-1426 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-6f1eb72d38eb4e598180d487f6164a8f2025-01-18T04:05:09ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262025-01-0113110.1136/jitc-2024-008876Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) reviewFrancesco M Marincola0Alessandra Cesano1Yana G Najjar2Davide Bedognetti3Marco Ruella4Sarah Warren5Christine Spencer6Elad Ziv7Tomas Kirchhoff8Jennifer McQuade9Tullia C Bruno10Jakob Nikolas Kather11Allison Betof Warner12Christian Hammer13Alberto Carturan14Ryan Augustin15Rhine Shen16Winson S Ho17Rongze O Lu18Luigi Barrea19Violena Pietrobon20Laura Soldati21Sonata Therapeutics Inc, Watertown, Massachusetts, USAESSA Pharma Inc, South San Francisco, California, USAUPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USAKite Pharma Inc, Santa Monica, California, USAUniversity of Pennsylvania, Philadelphia, Pennsylvania, USAKite Pharma Inc, Santa Monica, California, USAParker Institute for Cancer Immunotherapy, San Francisco, California, USAUniversity of California San Francisco, San Francisco, California, USALaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York University Langone Health, New York, NY, USAUniversity of Texas MD Anderson Cancer Center, Houston, Texas, USAUniversity of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USAElse Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, GermanyStanford University School of Medicine, Stanford, California, USAAltos Labs Inc, San Fransisco, California, USAUniversity of Pennsylvania, Philadelphia, Pennsylvania, USAUniversity of Pittsburgh Department of Medicine, Pittsburgh, Pennsylvania, USAKite Pharma Inc, Santa Monica, California, USAUniversity of California San Francisco, San Francisco, California, USAUCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USAUniversità Telematica Pegaso, Naples, ItalyKite Pharma Inc, Santa Monica, California, USAUniversity of Milan, Milan, ItalyCancer immunotherapy—including immune checkpoint inhibition (ICI) and adoptive cell therapy (ACT)—has become a standard, potentially curative treatment for a subset of advanced solid and liquid tumors. However, most patients with cancer do not benefit from the rapidly evolving improvements in the understanding of principal mechanisms determining cancer immune responsiveness (CIR); including patient-specific genetically determined and acquired factors, as well as intrinsic cancer cell biology. Though CIR is multifactorial, fundamental concepts are emerging that should be considered for the design of novel therapeutic strategies and related clinical studies. Recent advancements as well as novel approaches to address the limitations of current treatments are discussed here, with a specific focus on ICI and ACT.https://jitc.bmj.com/content/13/1/e008876.full |
| spellingShingle | Francesco M Marincola Alessandra Cesano Yana G Najjar Davide Bedognetti Marco Ruella Sarah Warren Christine Spencer Elad Ziv Tomas Kirchhoff Jennifer McQuade Tullia C Bruno Jakob Nikolas Kather Allison Betof Warner Christian Hammer Alberto Carturan Ryan Augustin Rhine Shen Winson S Ho Rongze O Lu Luigi Barrea Violena Pietrobon Laura Soldati Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review Journal for ImmunoTherapy of Cancer |
| title | Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review |
| title_full | Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review |
| title_fullStr | Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review |
| title_full_unstemmed | Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review |
| title_short | Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review |
| title_sort | advances in the understanding and therapeutic manipulation of cancer immune responsiveness a society for immunotherapy of cancer sitc review |
| url | https://jitc.bmj.com/content/13/1/e008876.full |
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