Green and Eco-Friendly Multicomponent Synthesis of 2-Hydroxypyridines Under Free Solvent Conditions
2-Hydroxypyridines (or commonly named 2-pyridones) are widespread nitrogen heterocycles in natural and synthetic products and their applications in biological, pharmaceutical and agrochemical compounds are becoming increasingly important. Therefore, several procedures have been described in the lite...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Chemistry Proceedings |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4583/14/1/109 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846105285555388416 |
|---|---|
| author | Djamila Benzenine Fatima Belhadj Zahira Kibou M. Pilar Vázquez-Tato Julio A. Seijas Noureddine Choukchou-Braham |
| author_facet | Djamila Benzenine Fatima Belhadj Zahira Kibou M. Pilar Vázquez-Tato Julio A. Seijas Noureddine Choukchou-Braham |
| author_sort | Djamila Benzenine |
| collection | DOAJ |
| description | 2-Hydroxypyridines (or commonly named 2-pyridones) are widespread nitrogen heterocycles in natural and synthetic products and their applications in biological, pharmaceutical and agrochemical compounds are becoming increasingly important. Therefore, several procedures have been described in the literature for the preparation of this heterocyclic framework. Among them, multicomponent reactions are the currently practiced method in synthetic organic chemistry, where reduced reaction times, high yields, and ease of product isolation are the main benefits of this method. In order to study the effect of the aforementioned method under greener medium, we herein describe a novel one-pot route for the design of 4,6-diaryl-3-cyano-2-pyridone derivatives under free solvent conditions. The three-component condensation of alkenes, ketones, and ammonium acetate efficiently resulted in the target heterocycles, with higher yields within a short time reaction compared to the classical method. |
| format | Article |
| id | doaj-art-6ed2d26ffebc4073a19a2f4ce11b2858 |
| institution | Kabale University |
| issn | 2673-4583 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry Proceedings |
| spelling | doaj-art-6ed2d26ffebc4073a19a2f4ce11b28582024-12-27T14:17:36ZengMDPI AGChemistry Proceedings2673-45832023-11-0114110910.3390/ecsoc-27-16297Green and Eco-Friendly Multicomponent Synthesis of 2-Hydroxypyridines Under Free Solvent ConditionsDjamila Benzenine0Fatima Belhadj1Zahira Kibou2M. Pilar Vázquez-Tato3Julio A. Seijas4Noureddine Choukchou-Braham5Laboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, B.P. 119, Tlemcen 13000, AlgeriaLaboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, B.P. 119, Tlemcen 13000, AlgeriaLaboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, B.P. 119, Tlemcen 13000, AlgeriaDepartamento de Química Orgánica, Facultad de Ciencias, Universidad of Santiago De Compostela, Alfonso X elSabio, 27002 Lugo, SpainDepartamento de Química Orgánica, Facultad de Ciencias, Universidad of Santiago De Compostela, Alfonso X elSabio, 27002 Lugo, SpainLaboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, B.P. 119, Tlemcen 13000, Algeria2-Hydroxypyridines (or commonly named 2-pyridones) are widespread nitrogen heterocycles in natural and synthetic products and their applications in biological, pharmaceutical and agrochemical compounds are becoming increasingly important. Therefore, several procedures have been described in the literature for the preparation of this heterocyclic framework. Among them, multicomponent reactions are the currently practiced method in synthetic organic chemistry, where reduced reaction times, high yields, and ease of product isolation are the main benefits of this method. In order to study the effect of the aforementioned method under greener medium, we herein describe a novel one-pot route for the design of 4,6-diaryl-3-cyano-2-pyridone derivatives under free solvent conditions. The three-component condensation of alkenes, ketones, and ammonium acetate efficiently resulted in the target heterocycles, with higher yields within a short time reaction compared to the classical method.https://www.mdpi.com/2673-4583/14/1/109green chemistrymulticomponentnitrogen-heterocycles2-Hydroxypyridinessolventless conditions |
| spellingShingle | Djamila Benzenine Fatima Belhadj Zahira Kibou M. Pilar Vázquez-Tato Julio A. Seijas Noureddine Choukchou-Braham Green and Eco-Friendly Multicomponent Synthesis of 2-Hydroxypyridines Under Free Solvent Conditions Chemistry Proceedings green chemistry multicomponent nitrogen-heterocycles 2-Hydroxypyridines solventless conditions |
| title | Green and Eco-Friendly Multicomponent Synthesis of 2-Hydroxypyridines Under Free Solvent Conditions |
| title_full | Green and Eco-Friendly Multicomponent Synthesis of 2-Hydroxypyridines Under Free Solvent Conditions |
| title_fullStr | Green and Eco-Friendly Multicomponent Synthesis of 2-Hydroxypyridines Under Free Solvent Conditions |
| title_full_unstemmed | Green and Eco-Friendly Multicomponent Synthesis of 2-Hydroxypyridines Under Free Solvent Conditions |
| title_short | Green and Eco-Friendly Multicomponent Synthesis of 2-Hydroxypyridines Under Free Solvent Conditions |
| title_sort | green and eco friendly multicomponent synthesis of 2 hydroxypyridines under free solvent conditions |
| topic | green chemistry multicomponent nitrogen-heterocycles 2-Hydroxypyridines solventless conditions |
| url | https://www.mdpi.com/2673-4583/14/1/109 |
| work_keys_str_mv | AT djamilabenzenine greenandecofriendlymulticomponentsynthesisof2hydroxypyridinesunderfreesolventconditions AT fatimabelhadj greenandecofriendlymulticomponentsynthesisof2hydroxypyridinesunderfreesolventconditions AT zahirakibou greenandecofriendlymulticomponentsynthesisof2hydroxypyridinesunderfreesolventconditions AT mpilarvazqueztato greenandecofriendlymulticomponentsynthesisof2hydroxypyridinesunderfreesolventconditions AT julioaseijas greenandecofriendlymulticomponentsynthesisof2hydroxypyridinesunderfreesolventconditions AT noureddinechoukchoubraham greenandecofriendlymulticomponentsynthesisof2hydroxypyridinesunderfreesolventconditions |