Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective
Abstract This study aims to explore the relationship between the albumin-corrected anion gap (ACAG) and short- and long-term all-cause mortality (ACM) in patients with acute pancreatitis (AP) managed in the intensive care unit (ICU). We conducted a retrospective analysis utilizing data extracted fro...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-85773-x |
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| author | Jianjun Wang Pei Yang Xintao Zeng Sirui Chen Xi Chen Lan Deng Ruizi Shi Chuan Qin Huiwen Luo Jianping Gong Hua Luo Decai Wang |
| author_facet | Jianjun Wang Pei Yang Xintao Zeng Sirui Chen Xi Chen Lan Deng Ruizi Shi Chuan Qin Huiwen Luo Jianping Gong Hua Luo Decai Wang |
| author_sort | Jianjun Wang |
| collection | DOAJ |
| description | Abstract This study aims to explore the relationship between the albumin-corrected anion gap (ACAG) and short- and long-term all-cause mortality (ACM) in patients with acute pancreatitis (AP) managed in the intensive care unit (ICU). We conducted a retrospective analysis utilizing data extracted from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. This study sought to investigate the correlation between ACAG and ACM among patients diagnosed with AP across various disease stages. R statistical software was used to identify the optimal thresholds for ACAG. Kaplan-Meier survival curves and multivariate Cox proportional hazards regression models were employed to assess the association between ACAG and short- and long-term ACM of AP. The predictive ability, sensitivity, specificity, and area under the curve (AUC) of ACAG for short- and long-term ACM in AP were investigated using receiver operating characteristic analysis. Subgroup analyses were also conducted. A cohort comprising 605 participants was included in this study. The ideal threshold for ACAG identified by R statistical software was 21.5. Cox proportional hazards modeling revealed that there was an independent association between patients with AP with ACAG ≥ 21.5 and ACM at 3, 7, 10, 14, 28, 90, and 180 days and 1 year before and after adjustment for confounders. Survival curves demonstrated that patients with ACAG ≥ 21.5 had lower survival rates at 3, 7, 10, 14, 28, 90, and 180 days and 1 year. In addition, ACAG showed superior performance, with a larger AUC than the anion gap, albumin, and Systemic Inflammatory Response Syndrome score and Sequential Organ Failure Assessment at 3, 7, 10, 14, 28, 90, and 180 days and 1 year. Subgroup analysis revealed no significant interaction between ACAG and any subgroups Elevated levels of ACAG were found to be associated with increased short- and long-term ACM in patients with AP, and ACAG may be an independent predictor of ACM at different disease stages. |
| format | Article |
| id | doaj-art-6ea29d5aaace4b5aa41997655a88a3dd |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-6ea29d5aaace4b5aa41997655a88a3dd2025-01-12T12:15:58ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-85773-xPrognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspectiveJianjun Wang0Pei Yang1Xintao Zeng2Sirui Chen3Xi Chen4Lan Deng5Ruizi Shi6Chuan Qin7Huiwen Luo8Jianping Gong9Hua Luo10Decai Wang11Department of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaNHC Key Laboratory of Nuclear Technology Medical Transformation, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaNHC Key Laboratory of Nuclear Technology Medical Transformation, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaAbstract This study aims to explore the relationship between the albumin-corrected anion gap (ACAG) and short- and long-term all-cause mortality (ACM) in patients with acute pancreatitis (AP) managed in the intensive care unit (ICU). We conducted a retrospective analysis utilizing data extracted from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. This study sought to investigate the correlation between ACAG and ACM among patients diagnosed with AP across various disease stages. R statistical software was used to identify the optimal thresholds for ACAG. Kaplan-Meier survival curves and multivariate Cox proportional hazards regression models were employed to assess the association between ACAG and short- and long-term ACM of AP. The predictive ability, sensitivity, specificity, and area under the curve (AUC) of ACAG for short- and long-term ACM in AP were investigated using receiver operating characteristic analysis. Subgroup analyses were also conducted. A cohort comprising 605 participants was included in this study. The ideal threshold for ACAG identified by R statistical software was 21.5. Cox proportional hazards modeling revealed that there was an independent association between patients with AP with ACAG ≥ 21.5 and ACM at 3, 7, 10, 14, 28, 90, and 180 days and 1 year before and after adjustment for confounders. Survival curves demonstrated that patients with ACAG ≥ 21.5 had lower survival rates at 3, 7, 10, 14, 28, 90, and 180 days and 1 year. In addition, ACAG showed superior performance, with a larger AUC than the anion gap, albumin, and Systemic Inflammatory Response Syndrome score and Sequential Organ Failure Assessment at 3, 7, 10, 14, 28, 90, and 180 days and 1 year. Subgroup analysis revealed no significant interaction between ACAG and any subgroups Elevated levels of ACAG were found to be associated with increased short- and long-term ACM in patients with AP, and ACAG may be an independent predictor of ACM at different disease stages.https://doi.org/10.1038/s41598-025-85773-xAlbumin-corrected anion gapAcute pancreatitisIntensive care unitAll-cause mortalityMIMIC-IV |
| spellingShingle | Jianjun Wang Pei Yang Xintao Zeng Sirui Chen Xi Chen Lan Deng Ruizi Shi Chuan Qin Huiwen Luo Jianping Gong Hua Luo Decai Wang Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective Scientific Reports Albumin-corrected anion gap Acute pancreatitis Intensive care unit All-cause mortality MIMIC-IV |
| title | Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective |
| title_full | Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective |
| title_fullStr | Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective |
| title_full_unstemmed | Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective |
| title_short | Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective |
| title_sort | prognostic significance of albumin corrected anion gap in patients with acute pancreatitis a novel perspective |
| topic | Albumin-corrected anion gap Acute pancreatitis Intensive care unit All-cause mortality MIMIC-IV |
| url | https://doi.org/10.1038/s41598-025-85773-x |
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