Impact of Human Papillomavirus (HPV) on Male and Female Fertility
Human papillomaviruses (HPVs) are responsible for the majority of sexually transmitted infections (STIs), some of which are oncogenic and can cause oropharyngeal or genital cancers. The HPV prevalence at the genital level varies according to the population studied but is higher in the seminal fluid...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2076-0817/13/12/1076 |
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| author | Sara Chenafi-Adham Oulfa Boussetta-Charfi Sylvie Pillet Thomas Bourlet |
| author_facet | Sara Chenafi-Adham Oulfa Boussetta-Charfi Sylvie Pillet Thomas Bourlet |
| author_sort | Sara Chenafi-Adham |
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| description | Human papillomaviruses (HPVs) are responsible for the majority of sexually transmitted infections (STIs), some of which are oncogenic and can cause oropharyngeal or genital cancers. The HPV prevalence at the genital level varies according to the population studied but is higher in the seminal fluid of men suffering from idiopathic infertility than in the general population. The involvement of HPV in male infertility is supported by several studies suggesting that this virus can affect sperm quality by altering sperm DNA integrity, motility, number, viability, and morphology, and by inducing the production of anti-sperm antibodies (ASAs). HPVs may also have an impact on female fertility, mainly by increasing the risk of miscarriage and premature delivery and by altering the implantation of endometrial trophoblastic cells. In addition, an association with vaginal bacterial dysbiosis, notably involving <i>Gardnerella vaginalis</i>, or co-infection with an STI agent, serves as an aggravating factor. The aim of this review is to present current data on the potential role of HPVs in male and female infertility, along with data on infertility prevention and treatment strategies and the impact of vaccination in this context. |
| format | Article |
| id | doaj-art-6e950c8d4fdd4d8da36d9dc51f6b5c6b |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Pathogens |
| spelling | doaj-art-6e950c8d4fdd4d8da36d9dc51f6b5c6b2024-12-27T14:45:19ZengMDPI AGPathogens2076-08172024-12-011312107610.3390/pathogens13121076Impact of Human Papillomavirus (HPV) on Male and Female FertilitySara Chenafi-Adham0Oulfa Boussetta-Charfi1Sylvie Pillet2Thomas Bourlet3Department of Infectious Agents and Hygiene, University Hospital of Saint-Etienne, 42023 Saint-Etienne, FranceDepartment of Infectious Agents and Hygiene, University Hospital of Saint-Etienne, 42023 Saint-Etienne, FranceDepartment of Infectious Agents and Hygiene, University Hospital of Saint-Etienne, 42023 Saint-Etienne, FranceDepartment of Infectious Agents and Hygiene, University Hospital of Saint-Etienne, 42023 Saint-Etienne, FranceHuman papillomaviruses (HPVs) are responsible for the majority of sexually transmitted infections (STIs), some of which are oncogenic and can cause oropharyngeal or genital cancers. The HPV prevalence at the genital level varies according to the population studied but is higher in the seminal fluid of men suffering from idiopathic infertility than in the general population. The involvement of HPV in male infertility is supported by several studies suggesting that this virus can affect sperm quality by altering sperm DNA integrity, motility, number, viability, and morphology, and by inducing the production of anti-sperm antibodies (ASAs). HPVs may also have an impact on female fertility, mainly by increasing the risk of miscarriage and premature delivery and by altering the implantation of endometrial trophoblastic cells. In addition, an association with vaginal bacterial dysbiosis, notably involving <i>Gardnerella vaginalis</i>, or co-infection with an STI agent, serves as an aggravating factor. The aim of this review is to present current data on the potential role of HPVs in male and female infertility, along with data on infertility prevention and treatment strategies and the impact of vaccination in this context.https://www.mdpi.com/2076-0817/13/12/1076human papillomavirusinfertilityscreeningvaccination |
| spellingShingle | Sara Chenafi-Adham Oulfa Boussetta-Charfi Sylvie Pillet Thomas Bourlet Impact of Human Papillomavirus (HPV) on Male and Female Fertility Pathogens human papillomavirus infertility screening vaccination |
| title | Impact of Human Papillomavirus (HPV) on Male and Female Fertility |
| title_full | Impact of Human Papillomavirus (HPV) on Male and Female Fertility |
| title_fullStr | Impact of Human Papillomavirus (HPV) on Male and Female Fertility |
| title_full_unstemmed | Impact of Human Papillomavirus (HPV) on Male and Female Fertility |
| title_short | Impact of Human Papillomavirus (HPV) on Male and Female Fertility |
| title_sort | impact of human papillomavirus hpv on male and female fertility |
| topic | human papillomavirus infertility screening vaccination |
| url | https://www.mdpi.com/2076-0817/13/12/1076 |
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