Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunities
Polycystic ovary syndrome (PCOS), a common yet intricate endocrine disorder, presents persistent clinical challenges due to its complex pathogenesis. Reactive oxygen species (ROS), highly reactive molecules, have emerged as critical contributors to PCOS development and represent potential therapeuti...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Redox Biology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231725002897 |
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| author | Huanju Liu Lihao Jin Xiaoya Wang Junling Shi Yujie He Ningxia Sun Fu Yang |
| author_facet | Huanju Liu Lihao Jin Xiaoya Wang Junling Shi Yujie He Ningxia Sun Fu Yang |
| author_sort | Huanju Liu |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS), a common yet intricate endocrine disorder, presents persistent clinical challenges due to its complex pathogenesis. Reactive oxygen species (ROS), highly reactive molecules, have emerged as critical contributors to PCOS development and represent potential therapeutic targets. This review comprehensively explores the diverse roles of ROS in PCOS pathogenesis, particularly their contributions to metabolic dysfunction and hormonal imbalance. It further assesses the therapeutic potential of ROS-targeted interventions, summarizing antioxidant therapy advancements, underlying mechanisms, and current challenges. By consolidating recent research, this review highlights the profound significance of ROS in PCOS, aiming to inspire innovative pathogenesis research, improve clinical management, and establish a robust theoretical foundation for more effective PCOS treatment strategies. |
| format | Article |
| id | doaj-art-6e90d9d4a8d943b79f23a0f61fc9ce93 |
| institution | Kabale University |
| issn | 2213-2317 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj-art-6e90d9d4a8d943b79f23a0f61fc9ce932025-08-24T05:12:37ZengElsevierRedox Biology2213-23172025-09-018510377610.1016/j.redox.2025.103776Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunitiesHuanju Liu0Lihao Jin1Xiaoya Wang2Junling Shi3Yujie He4Ningxia Sun5Fu Yang6Department of Medical Genetics, Naval Medical University, Shanghai, ChinaDepartment of Medical Genetics, Naval Medical University, Shanghai, ChinaInstitute of Genetics, International School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCenter for Reproductive Medicine, Second Affiliated Hospital of Naval Medical University, Shanghai, ChinaCenter for Reproductive Medicine, Second Affiliated Hospital of Naval Medical University, Shanghai, China; Corresponding author. 800 Xiangyin Road, Yangpu District, Shanghai, 200433, China.Department of Medical Genetics, Naval Medical University, Shanghai, China; Center for Reproductive Medicine, Second Affiliated Hospital of Naval Medical University, Shanghai, China; Corresponding author. Department of Medical Genetics, Naval Medical University, Shanghai, China.Polycystic ovary syndrome (PCOS), a common yet intricate endocrine disorder, presents persistent clinical challenges due to its complex pathogenesis. Reactive oxygen species (ROS), highly reactive molecules, have emerged as critical contributors to PCOS development and represent potential therapeutic targets. This review comprehensively explores the diverse roles of ROS in PCOS pathogenesis, particularly their contributions to metabolic dysfunction and hormonal imbalance. It further assesses the therapeutic potential of ROS-targeted interventions, summarizing antioxidant therapy advancements, underlying mechanisms, and current challenges. By consolidating recent research, this review highlights the profound significance of ROS in PCOS, aiming to inspire innovative pathogenesis research, improve clinical management, and establish a robust theoretical foundation for more effective PCOS treatment strategies.http://www.sciencedirect.com/science/article/pii/S2213231725002897Reactive oxygen speciesPolycystic ovary syndromeMetabolismTargets |
| spellingShingle | Huanju Liu Lihao Jin Xiaoya Wang Junling Shi Yujie He Ningxia Sun Fu Yang Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunities Redox Biology Reactive oxygen species Polycystic ovary syndrome Metabolism Targets |
| title | Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunities |
| title_full | Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunities |
| title_fullStr | Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunities |
| title_full_unstemmed | Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunities |
| title_short | Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunities |
| title_sort | reactive oxygen species in polycystic ovary syndrome mechanistic insights into pathogenesis and therapeutic opportunities |
| topic | Reactive oxygen species Polycystic ovary syndrome Metabolism Targets |
| url | http://www.sciencedirect.com/science/article/pii/S2213231725002897 |
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