Prognostic significance of blood immune cells in children with sepsis and establishment of a predictive model for PICU mortality: a retrospective study
ObjectivesThis article aimed to investigate the correlation between blood immune cells and the prognosis in the early phase of pediatric sepsis and construct a prediction model for pediatric intensive care unit (PICU) mortality.MethodsA total of 348 children admitted with sepsis to our PICU were ret...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1455216/full |
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| author | Mulan He Qiuxia Meng Zhixin Wei Zhiyong Yang |
| author_facet | Mulan He Qiuxia Meng Zhixin Wei Zhiyong Yang |
| author_sort | Mulan He |
| collection | DOAJ |
| description | ObjectivesThis article aimed to investigate the correlation between blood immune cells and the prognosis in the early phase of pediatric sepsis and construct a prediction model for pediatric intensive care unit (PICU) mortality.MethodsA total of 348 children admitted with sepsis to our PICU were retrospectively collected between January 2020 and June 2024. Of these, 242 children admitted from January 2020 to October 2022 were designated as the modeling group, while 106 children admitted between November 2022 and June 2024 were designated as the prospective validation group. Peripheral blood immune-related parameters, measured from the day of PICU admission to day 7, were analyzed in the modeling group. Risk factors were identified through multivariate logistic regression and integrated into a predictive nomogram. The nomogram was then applied to the prospective validation group to assess its discrimination and calibration. The nomogram's performance was evaluated using the area under the receiver operating characteristic curves (AUC), calibration plots, and decision curve analysis for both groups.ResultsComplicated with underlying diseases, invasive mechanical ventilation, increased pediatric risk of mortality score or pediatric sequential organ failure assessment score, and lymphopenia (d1) were independent risk factors for PICU mortality. The 90-day survival of patients with lymphopenia on the first day after admission was low. In addition, patients with persistent lymphopenia had higher mortality. The nomogram showed an AUC of 0.861 (95% CI: 0.813 to 0.909) in the modeling group and 0.875 (95% CI: 0.797 to 0.953) in the prospective validation group. The nomogram also performed well based on the calibration curve and decision curve analysis.ConclusionAssessing lymphocytes within seven days of PICU admission may be conducive to identifying children with sepsis at increased mortality risk. The nomogram performed well in predicting PICU mortality among patients of interest. |
| format | Article |
| id | doaj-art-6e900b99ceea4d54b038d0f23bfc621b |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-6e900b99ceea4d54b038d0f23bfc621b2024-12-12T06:18:41ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-12-011210.3389/fped.2024.14552161455216Prognostic significance of blood immune cells in children with sepsis and establishment of a predictive model for PICU mortality: a retrospective studyMulan HeQiuxia MengZhixin WeiZhiyong YangObjectivesThis article aimed to investigate the correlation between blood immune cells and the prognosis in the early phase of pediatric sepsis and construct a prediction model for pediatric intensive care unit (PICU) mortality.MethodsA total of 348 children admitted with sepsis to our PICU were retrospectively collected between January 2020 and June 2024. Of these, 242 children admitted from January 2020 to October 2022 were designated as the modeling group, while 106 children admitted between November 2022 and June 2024 were designated as the prospective validation group. Peripheral blood immune-related parameters, measured from the day of PICU admission to day 7, were analyzed in the modeling group. Risk factors were identified through multivariate logistic regression and integrated into a predictive nomogram. The nomogram was then applied to the prospective validation group to assess its discrimination and calibration. The nomogram's performance was evaluated using the area under the receiver operating characteristic curves (AUC), calibration plots, and decision curve analysis for both groups.ResultsComplicated with underlying diseases, invasive mechanical ventilation, increased pediatric risk of mortality score or pediatric sequential organ failure assessment score, and lymphopenia (d1) were independent risk factors for PICU mortality. The 90-day survival of patients with lymphopenia on the first day after admission was low. In addition, patients with persistent lymphopenia had higher mortality. The nomogram showed an AUC of 0.861 (95% CI: 0.813 to 0.909) in the modeling group and 0.875 (95% CI: 0.797 to 0.953) in the prospective validation group. The nomogram also performed well based on the calibration curve and decision curve analysis.ConclusionAssessing lymphocytes within seven days of PICU admission may be conducive to identifying children with sepsis at increased mortality risk. The nomogram performed well in predicting PICU mortality among patients of interest.https://www.frontiersin.org/articles/10.3389/fped.2024.1455216/fullsepsischildrenpredictive modellymphocytesPICU mortality |
| spellingShingle | Mulan He Qiuxia Meng Zhixin Wei Zhiyong Yang Prognostic significance of blood immune cells in children with sepsis and establishment of a predictive model for PICU mortality: a retrospective study Frontiers in Pediatrics sepsis children predictive model lymphocytes PICU mortality |
| title | Prognostic significance of blood immune cells in children with sepsis and establishment of a predictive model for PICU mortality: a retrospective study |
| title_full | Prognostic significance of blood immune cells in children with sepsis and establishment of a predictive model for PICU mortality: a retrospective study |
| title_fullStr | Prognostic significance of blood immune cells in children with sepsis and establishment of a predictive model for PICU mortality: a retrospective study |
| title_full_unstemmed | Prognostic significance of blood immune cells in children with sepsis and establishment of a predictive model for PICU mortality: a retrospective study |
| title_short | Prognostic significance of blood immune cells in children with sepsis and establishment of a predictive model for PICU mortality: a retrospective study |
| title_sort | prognostic significance of blood immune cells in children with sepsis and establishment of a predictive model for picu mortality a retrospective study |
| topic | sepsis children predictive model lymphocytes PICU mortality |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1455216/full |
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