From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease

From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease

Abstract Parkinson disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy are synucleinopathies, characterized by neuronal loss, gliosis and the abnormal deposition of α-synuclein in vulnerable areas of the nervous system. Neurodegeneration begins however several years before clin...

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Main Authors: Ambra Stefani, Elena Antelmi, Dario Arnaldi, Isabelle Arnulf, Emmanuel During, Birgit Högl, Michele M. T. Hu, Alex Iranzo, Russell Luke, John Peever, Ronald B. Postuma, Aleksandar Videnovic, Ziv Gan-Or
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Neurodegeneration
Online Access:https://doi.org/10.1186/s13024-025-00809-0
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