Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes
Abstract Type 2 diabetes (T2D) is a common comorbidity in kidney transplant recipients, representing a significant proportion of the candidate pool. Post-kidney transplantation management of T2D remains challenging, leading to inferior long-term outcomes compared to non-diabetic recipients. This stu...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83817-2 |
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| author | Mehdi Maanaoui Florence Debillon Rémi Lenain Frédérique Defrance Marie-Christine Vantyghem Marine Van Triempont François Provôt Mikael Chetboun Julie Kerr-Conte Aghiles Hamroun Marie Frimat Violeta Raverdy François Pattou Marc Hazzan François Glowacki |
| author_facet | Mehdi Maanaoui Florence Debillon Rémi Lenain Frédérique Defrance Marie-Christine Vantyghem Marine Van Triempont François Provôt Mikael Chetboun Julie Kerr-Conte Aghiles Hamroun Marie Frimat Violeta Raverdy François Pattou Marc Hazzan François Glowacki |
| author_sort | Mehdi Maanaoui |
| collection | DOAJ |
| description | Abstract Type 2 diabetes (T2D) is a common comorbidity in kidney transplant recipients, representing a significant proportion of the candidate pool. Post-kidney transplantation management of T2D remains challenging, leading to inferior long-term outcomes compared to non-diabetic recipients. This study aimed to assess the association between Homeostatic Model Assessment 2 (HOMA2) derived insulin resistance and beta-cell function on kidney graft outcomes in T2D kidney transplant recipients. We conducted a monocentric retrospective study at the University Hospital of Lille, including all consecutive adult T2D patients who underwent kidney transplantation between January 2007 and December 2018. HOMA2 indexes (HOMA2 IR for insulin resistance and HOMA2 B for beta-cell function) were calculated at one-year post-transplantation. Primary endpoint was graft survival and secondary endpoints were death-censored graft survival, patient survival and post-transplant metabolic control. Among 1620 kidney transplant recipients, 138 patients with T2D were included, with a median follow-up of 1837 days [1283–2726]. HOMA2 IR was significantly associated with an increased risk of kidney graft failure or death (HR per unit = 1.11 (1.02–1.21). Beta-cell function was not associated with graft prognosis, but decreased beta-cell function was associated with poorer metabolic control over time. This study highlights the significance of insulin resistance as a potential determinant of long-term outcomes in T2D kidney transplant recipients. |
| format | Article |
| id | doaj-art-6e7eab811ec144f4b760250d479c0b92 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6e7eab811ec144f4b760250d479c0b922025-01-05T12:24:37ZengNature PortfolioScientific Reports2045-23222024-12-0114111010.1038/s41598-024-83817-2Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetesMehdi Maanaoui0Florence Debillon1Rémi Lenain2Frédérique Defrance3Marie-Christine Vantyghem4Marine Van Triempont5François Provôt6Mikael Chetboun7Julie Kerr-Conte8Aghiles Hamroun9Marie Frimat10Violeta Raverdy11François Pattou12Marc Hazzan13François Glowacki14Department of Nephrology, CHU Lille, University of LilleDepartment of Nephrology, CHU Lille, University of LilleDepartment of Nephrology, CHU Lille, University of LilleU1190 Translational Research for Diabetes, INSERM, Institut Pasteur de Lille, Université LilleU1190 Translational Research for Diabetes, INSERM, Institut Pasteur de Lille, Université LilleDepartment of Nephrology, CHU Lille, University of LilleDepartment of Nephrology, CHU Lille, University of LilleU1190 Translational Research for Diabetes, INSERM, Institut Pasteur de Lille, Université LilleU1190 Translational Research for Diabetes, INSERM, Institut Pasteur de Lille, Université LilleSanté Publique, Epidémiologie - UMR 1167 Ridage, Institut Pasteur de Lille, Univ Lille, Chu LilleDepartment of Nephrology, CHU Lille, University of LilleU1190 Translational Research for Diabetes, INSERM, Institut Pasteur de Lille, Université LilleU1190 Translational Research for Diabetes, INSERM, Institut Pasteur de Lille, Université LilleDepartment of Nephrology, CHU Lille, University of LilleDepartment of Nephrology, CHU Lille, University of LilleAbstract Type 2 diabetes (T2D) is a common comorbidity in kidney transplant recipients, representing a significant proportion of the candidate pool. Post-kidney transplantation management of T2D remains challenging, leading to inferior long-term outcomes compared to non-diabetic recipients. This study aimed to assess the association between Homeostatic Model Assessment 2 (HOMA2) derived insulin resistance and beta-cell function on kidney graft outcomes in T2D kidney transplant recipients. We conducted a monocentric retrospective study at the University Hospital of Lille, including all consecutive adult T2D patients who underwent kidney transplantation between January 2007 and December 2018. HOMA2 indexes (HOMA2 IR for insulin resistance and HOMA2 B for beta-cell function) were calculated at one-year post-transplantation. Primary endpoint was graft survival and secondary endpoints were death-censored graft survival, patient survival and post-transplant metabolic control. Among 1620 kidney transplant recipients, 138 patients with T2D were included, with a median follow-up of 1837 days [1283–2726]. HOMA2 IR was significantly associated with an increased risk of kidney graft failure or death (HR per unit = 1.11 (1.02–1.21). Beta-cell function was not associated with graft prognosis, but decreased beta-cell function was associated with poorer metabolic control over time. This study highlights the significance of insulin resistance as a potential determinant of long-term outcomes in T2D kidney transplant recipients.https://doi.org/10.1038/s41598-024-83817-2HOMA2Insulin resistanceDiabetesKidney transplantation |
| spellingShingle | Mehdi Maanaoui Florence Debillon Rémi Lenain Frédérique Defrance Marie-Christine Vantyghem Marine Van Triempont François Provôt Mikael Chetboun Julie Kerr-Conte Aghiles Hamroun Marie Frimat Violeta Raverdy François Pattou Marc Hazzan François Glowacki Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes Scientific Reports HOMA2 Insulin resistance Diabetes Kidney transplantation |
| title | Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes |
| title_full | Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes |
| title_fullStr | Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes |
| title_full_unstemmed | Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes |
| title_short | Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes |
| title_sort | association between homa2 based beta cell function or insulin resistance and long term outcomes in kidney transplant recipients with type 2 diabetes |
| topic | HOMA2 Insulin resistance Diabetes Kidney transplantation |
| url | https://doi.org/10.1038/s41598-024-83817-2 |
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