Positron emission tomography for phenotyping inflammation of cardiovascular diseases
Inflammatory processes play a central role in the development and complications of cardiovascular diseases (CVDs), profoundly affecting the severity and prognosis of these events. However, the current tools used to measure inflammation have some limitations. Blood biomarkers cannot pinpoint the loca...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | EngMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S295048992400040X |
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| author | Xiaoyun Luo Chentao Jin Hetian Chen Xiaohui Zhang Yan Zhong Peili Cen Hong Zhang Mei Tian |
| author_facet | Xiaoyun Luo Chentao Jin Hetian Chen Xiaohui Zhang Yan Zhong Peili Cen Hong Zhang Mei Tian |
| author_sort | Xiaoyun Luo |
| collection | DOAJ |
| description | Inflammatory processes play a central role in the development and complications of cardiovascular diseases (CVDs), profoundly affecting the severity and prognosis of these events. However, the current tools used to measure inflammation have some limitations. Blood biomarkers cannot pinpoint the location of inflammation and are vulnerable to various factors. Histological assessments ex vivo cannot accurately reflect the full dynamic picture of pathophysiology. The rapid development of positron emission tomography (PET) imaging not only enhances our understanding of biological processes in vivo but also contributes significantly to clinical management as a non-invasive biomarker. This review summarizes the PET imaging of key immune cell responses in CVDs, including immune cell metabolism, ligand/receptor interactions, and enzyme secretion, and discusses emerging opportunities and challenges in PET imaging-based inflammatory phenotyping and future perspectives. |
| format | Article |
| id | doaj-art-6e7b5b8620ae42cea62eda0eae48b1e0 |
| institution | Kabale University |
| issn | 2950-4899 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EngMedicine |
| spelling | doaj-art-6e7b5b8620ae42cea62eda0eae48b1e02025-01-11T06:42:30ZengElsevierEngMedicine2950-48992024-12-0113100040Positron emission tomography for phenotyping inflammation of cardiovascular diseasesXiaoyun Luo0Chentao Jin1Hetian Chen2Xiaohui Zhang3Yan Zhong4Peili Cen5Hong Zhang6Mei Tian7Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang, 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang, 310009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang, 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang, 310009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang, 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang, 310009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang, 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang, 310009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang, 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang, 310009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang, 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang, 310009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang, 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang, 310009, China; College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, 310014, China; Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, Zhejiang, 310014, China; Corresponding author. Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang, 310009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang, 310009, China; Human Phenome Institute, Fudan University, Shanghai, 201203, China; Corresponding author. Human Phenome Institute, Fudan University, Shanghai, 201203, ChinaInflammatory processes play a central role in the development and complications of cardiovascular diseases (CVDs), profoundly affecting the severity and prognosis of these events. However, the current tools used to measure inflammation have some limitations. Blood biomarkers cannot pinpoint the location of inflammation and are vulnerable to various factors. Histological assessments ex vivo cannot accurately reflect the full dynamic picture of pathophysiology. The rapid development of positron emission tomography (PET) imaging not only enhances our understanding of biological processes in vivo but also contributes significantly to clinical management as a non-invasive biomarker. This review summarizes the PET imaging of key immune cell responses in CVDs, including immune cell metabolism, ligand/receptor interactions, and enzyme secretion, and discusses emerging opportunities and challenges in PET imaging-based inflammatory phenotyping and future perspectives.http://www.sciencedirect.com/science/article/pii/S295048992400040XPositron emission tomographyCardiovascular diseasesMolecular imagingInflammationImmune cells |
| spellingShingle | Xiaoyun Luo Chentao Jin Hetian Chen Xiaohui Zhang Yan Zhong Peili Cen Hong Zhang Mei Tian Positron emission tomography for phenotyping inflammation of cardiovascular diseases EngMedicine Positron emission tomography Cardiovascular diseases Molecular imaging Inflammation Immune cells |
| title | Positron emission tomography for phenotyping inflammation of cardiovascular diseases |
| title_full | Positron emission tomography for phenotyping inflammation of cardiovascular diseases |
| title_fullStr | Positron emission tomography for phenotyping inflammation of cardiovascular diseases |
| title_full_unstemmed | Positron emission tomography for phenotyping inflammation of cardiovascular diseases |
| title_short | Positron emission tomography for phenotyping inflammation of cardiovascular diseases |
| title_sort | positron emission tomography for phenotyping inflammation of cardiovascular diseases |
| topic | Positron emission tomography Cardiovascular diseases Molecular imaging Inflammation Immune cells |
| url | http://www.sciencedirect.com/science/article/pii/S295048992400040X |
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