Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects
Abstract The clinical treatments of maxillofacial bone defects pose significant challenges due to complex microenvironments, including severe inflammation, high levels of reactive oxygen species (ROS), and potential bacterial infection. Herein, we propose the de novo design of an efficient, versatil...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-53824-y |
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| author | Mingru Bai Ting Wang Zhenyu Xing Haoju Huang Xizheng Wu Mohsen Adeli Mao Wang Xianglong Han Ling Ye Chong Cheng |
| author_facet | Mingru Bai Ting Wang Zhenyu Xing Haoju Huang Xizheng Wu Mohsen Adeli Mao Wang Xianglong Han Ling Ye Chong Cheng |
| author_sort | Mingru Bai |
| collection | DOAJ |
| description | Abstract The clinical treatments of maxillofacial bone defects pose significant challenges due to complex microenvironments, including severe inflammation, high levels of reactive oxygen species (ROS), and potential bacterial infection. Herein, we propose the de novo design of an efficient, versatile, and precise electron-donable heterojunction with synergetic Ru-Cu pair sites (Ru-Cu/EDHJ) for superior biocatalytic regeneration of inflammatory mandible defects and pH-controlled antibacterial therapies. Our studies demonstrate that the unique structure of Ru-Cu/EDHJ enhances the electron density of Ru atoms and optimizes the binding strength of oxygen species, thus improving enzyme-like catalytic performance. Strikingly, this biocompatible Ru-Cu/EDHJ can efficiently switch between ROS scavenging in neutral media and ROS generation in acidic media, thus simultaneously exhibiting superior repair functions and bioadaptive antibacterial properties in treating mandible defects in male mice. We believe synthesizing such biocatalytic heterojunctions with exceptional enzyme-like capabilities will offer a promising pathway for engineering ROS biocatalytic materials to treat trauma, tumors, or infection-caused maxillofacial bone defects. |
| format | Article |
| id | doaj-art-6e6db56c2abf4f8e90dcb79fdfe6603d |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-6e6db56c2abf4f8e90dcb79fdfe6603d2024-11-10T12:34:10ZengNature PortfolioNature Communications2041-17232024-11-0115112210.1038/s41467-024-53824-yElectron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defectsMingru Bai0Ting Wang1Zhenyu Xing2Haoju Huang3Xizheng Wu4Mohsen Adeli5Mao Wang6Xianglong Han7Ling Ye8Chong Cheng9State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityInstitute of Chemistry and Biochemistry, Free University of BerlinCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityAbstract The clinical treatments of maxillofacial bone defects pose significant challenges due to complex microenvironments, including severe inflammation, high levels of reactive oxygen species (ROS), and potential bacterial infection. Herein, we propose the de novo design of an efficient, versatile, and precise electron-donable heterojunction with synergetic Ru-Cu pair sites (Ru-Cu/EDHJ) for superior biocatalytic regeneration of inflammatory mandible defects and pH-controlled antibacterial therapies. Our studies demonstrate that the unique structure of Ru-Cu/EDHJ enhances the electron density of Ru atoms and optimizes the binding strength of oxygen species, thus improving enzyme-like catalytic performance. Strikingly, this biocompatible Ru-Cu/EDHJ can efficiently switch between ROS scavenging in neutral media and ROS generation in acidic media, thus simultaneously exhibiting superior repair functions and bioadaptive antibacterial properties in treating mandible defects in male mice. We believe synthesizing such biocatalytic heterojunctions with exceptional enzyme-like capabilities will offer a promising pathway for engineering ROS biocatalytic materials to treat trauma, tumors, or infection-caused maxillofacial bone defects.https://doi.org/10.1038/s41467-024-53824-y |
| spellingShingle | Mingru Bai Ting Wang Zhenyu Xing Haoju Huang Xizheng Wu Mohsen Adeli Mao Wang Xianglong Han Ling Ye Chong Cheng Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects Nature Communications |
| title | Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects |
| title_full | Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects |
| title_fullStr | Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects |
| title_full_unstemmed | Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects |
| title_short | Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects |
| title_sort | electron donable heterojunctions with synergetic ru cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects |
| url | https://doi.org/10.1038/s41467-024-53824-y |
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