Experimental Study to Evaluate the Safety and Immunomodulatory Effect of Swarna Vacha Yog in Wistar Albino Rats
Introduction:Recently, concerns were raised about the safety of Ayurvedic medicines using Bhasma and concerns were expressed regarding the metal toxicity of traditional preparations containing Bhasmas. Hence, to analyze safety and immunomodulatory effect of an Ayurveda herbomineral preparation Swarn...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Ayurveda |
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| Online Access: | https://journals.lww.com/10.4103/joa.joa_271_21 |
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| author | Rashmi Pareek Nisha Kumari Ojha Sanjeev Sharma |
| author_facet | Rashmi Pareek Nisha Kumari Ojha Sanjeev Sharma |
| author_sort | Rashmi Pareek |
| collection | DOAJ |
| description | Introduction:Recently, concerns were raised about the safety of Ayurvedic medicines using Bhasma and concerns were expressed regarding the metal toxicity of traditional preparations containing Bhasmas. Hence, to analyze safety and immunomodulatory effect of an Ayurveda herbomineral preparation Swarna Vacha Yog, an experimental study was conducted in Wistar Albino Rats. The proposed formulation was intended for oral administration. Hence, the safety study was performed using OECD proposed Oral Toxicity Guidelines and was evaluated by response in Wistar Albino Rats.Methods:Nine healthy adult albino Wistar Albino Rats from both sexes were randomly selected for toxicity study which were divided into three groups (three in each group) and 24 selected randomly and divided in four groups for immunomodulatory effect.Results and Conclusion:No any evidence of acute toxicity was observed after giving test sample at dose of 50, 300 and 2000 mg/kg at 30 min, 4 h, 24 h, 48 h, 1 week, and 2 weeks. There was less reduction in total leukocyte count and neutrophil count (P < 0.0001) when trial drug was compared with normal control and standard control in cyclophosphamide-induced neutropenia rat model. |
| format | Article |
| id | doaj-art-6e6349e32f5f4872bcfce7fda918b91a |
| institution | Kabale University |
| issn | 2321-0435 2582-7693 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Ayurveda |
| spelling | doaj-art-6e6349e32f5f4872bcfce7fda918b91a2025-01-12T11:00:32ZengWolters Kluwer Medknow PublicationsJournal of Ayurveda2321-04352582-76932024-12-0118424825410.4103/joa.joa_271_21Experimental Study to Evaluate the Safety and Immunomodulatory Effect of Swarna Vacha Yog in Wistar Albino RatsRashmi PareekNisha Kumari OjhaSanjeev SharmaIntroduction:Recently, concerns were raised about the safety of Ayurvedic medicines using Bhasma and concerns were expressed regarding the metal toxicity of traditional preparations containing Bhasmas. Hence, to analyze safety and immunomodulatory effect of an Ayurveda herbomineral preparation Swarna Vacha Yog, an experimental study was conducted in Wistar Albino Rats. The proposed formulation was intended for oral administration. Hence, the safety study was performed using OECD proposed Oral Toxicity Guidelines and was evaluated by response in Wistar Albino Rats.Methods:Nine healthy adult albino Wistar Albino Rats from both sexes were randomly selected for toxicity study which were divided into three groups (three in each group) and 24 selected randomly and divided in four groups for immunomodulatory effect.Results and Conclusion:No any evidence of acute toxicity was observed after giving test sample at dose of 50, 300 and 2000 mg/kg at 30 min, 4 h, 24 h, 48 h, 1 week, and 2 weeks. There was less reduction in total leukocyte count and neutrophil count (P < 0.0001) when trial drug was compared with normal control and standard control in cyclophosphamide-induced neutropenia rat model.https://journals.lww.com/10.4103/joa.joa_271_21immunomodulatoryswarna-vacha yogtoxicitywistar albino rats |
| spellingShingle | Rashmi Pareek Nisha Kumari Ojha Sanjeev Sharma Experimental Study to Evaluate the Safety and Immunomodulatory Effect of Swarna Vacha Yog in Wistar Albino Rats Journal of Ayurveda immunomodulatory swarna-vacha yog toxicity wistar albino rats |
| title | Experimental Study to Evaluate the Safety and Immunomodulatory Effect of Swarna Vacha Yog in Wistar Albino Rats |
| title_full | Experimental Study to Evaluate the Safety and Immunomodulatory Effect of Swarna Vacha Yog in Wistar Albino Rats |
| title_fullStr | Experimental Study to Evaluate the Safety and Immunomodulatory Effect of Swarna Vacha Yog in Wistar Albino Rats |
| title_full_unstemmed | Experimental Study to Evaluate the Safety and Immunomodulatory Effect of Swarna Vacha Yog in Wistar Albino Rats |
| title_short | Experimental Study to Evaluate the Safety and Immunomodulatory Effect of Swarna Vacha Yog in Wistar Albino Rats |
| title_sort | experimental study to evaluate the safety and immunomodulatory effect of swarna vacha yog in wistar albino rats |
| topic | immunomodulatory swarna-vacha yog toxicity wistar albino rats |
| url | https://journals.lww.com/10.4103/joa.joa_271_21 |
| work_keys_str_mv | AT rashmipareek experimentalstudytoevaluatethesafetyandimmunomodulatoryeffectofswarnavachayoginwistaralbinorats AT nishakumariojha experimentalstudytoevaluatethesafetyandimmunomodulatoryeffectofswarnavachayoginwistaralbinorats AT sanjeevsharma experimentalstudytoevaluatethesafetyandimmunomodulatoryeffectofswarnavachayoginwistaralbinorats |