Biatrial and Biventricular Reference Ranges Based on Cardiac Magnetic Resonance in Sickle Cell Disease Patients Without Heart Damage
Background/Objectives: We aimed to establish biatrial and biventricular reference ranges using cardiac magnetic resonance (CMR) parameters in SCD patients without heart damage. Methods: This study compared CMR parameters, quantified by cine SSFP sequences, in 48 adult SCD patients without apparent c...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2075-4418/14/24/2816 |
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| author | Laura Pistoia Antonella Meloni Vincenzo Positano Alessandra Quota Elisabetta Corigliano Giuseppe Messina Stefania Renne Michela Zerbini Simona Romani Gianfranco Sinagra Lamia Ait Ali Sophie Mavrogeni Amalia Lupi Filippo Cademartiri Alessia Pepe |
| author_facet | Laura Pistoia Antonella Meloni Vincenzo Positano Alessandra Quota Elisabetta Corigliano Giuseppe Messina Stefania Renne Michela Zerbini Simona Romani Gianfranco Sinagra Lamia Ait Ali Sophie Mavrogeni Amalia Lupi Filippo Cademartiri Alessia Pepe |
| author_sort | Laura Pistoia |
| collection | DOAJ |
| description | Background/Objectives: We aimed to establish biatrial and biventricular reference ranges using cardiac magnetic resonance (CMR) parameters in SCD patients without heart damage. Methods: This study compared CMR parameters, quantified by cine SSFP sequences, in 48 adult SCD patients without apparent cardiac involvement (defined by the absence of known risk factors, normal electrocardiogram, and no macroscopic myocardial fibrosis or significant cardiac iron on T2* CMR) to matched cohorts of 96 healthy controls and 96 thalassemia major (TM) patients without cardiac damage. Nine paediatric SCD patients were also analysed and compared to age- and gender-matched groups of nine TM patients and nine healthy subjects. Results: In all groups, studied males displayed higher biventricular volumes and mass indexes than females. Male SCD patients showed significantly higher left ventricular (LV) end-diastolic volume index (EDVI), LV end-systolic volume index (ESVI), LV stroke volume index (SVI), cardiac index, LV and right ventricular (RV) mass index, and atrial areas than healthy subjects. Females with SCD exhibited increased LV EDVI, LV SVI, RV mass index, and left atrial area index compared to healthy controls. SCD and TM patients showed comparable biatrial areas and biventricular volumes and function. When compared to TM, SCD males exhibited a larger mass index, while SCD females showed an increased RV mass index. CMR parameters were similar across all paediatric groups. Conclusions: By establishing the biatrial and biventricular reference ranges through CMR for adult male and female SCD patients, we aimed to prevent possible misdiagnosis of cardiomyopathy in this population by taking into account cardiac adaptation due to anaemia. |
| format | Article |
| id | doaj-art-6e4ee923a0224f3d8fd6f43dddae488f |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-6e4ee923a0224f3d8fd6f43dddae488f2024-12-27T14:20:50ZengMDPI AGDiagnostics2075-44182024-12-011424281610.3390/diagnostics14242816Biatrial and Biventricular Reference Ranges Based on Cardiac Magnetic Resonance in Sickle Cell Disease Patients Without Heart DamageLaura Pistoia0Antonella Meloni1Vincenzo Positano2Alessandra Quota3Elisabetta Corigliano4Giuseppe Messina5Stefania Renne6Michela Zerbini7Simona Romani8Gianfranco Sinagra9Lamia Ait Ali10Sophie Mavrogeni11Amalia Lupi12Filippo Cademartiri13Alessia Pepe14U.O.C. Ricerca Clinica, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, ItalyDepartment of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, ItalyDepartment of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, ItalyServizio di Talassemia, Ospedale “V. Emanuele III”, 93012 Gela, ItalyEmatologia Microcitemia, Ospedale San Giovanni di Dio—ASP Crotone, 88900 Crotone, ItalyCentro Microcitemie, Grande Ospedale Metropolitano “Bianchi-Melacrino-Morelli”, 89100 Reggio Calabria, ItalyStruttura Complessa di Cardioradiologia-UTIC, Presidio Ospedaliero “Giovanni Paolo II”, 88046 Lamezia Terme, ItalyDiagnostica per Immagini e Radiologia Interventistica, Ospedale del Delta, 44023 Lagosanto, ItalyDipartimento Cardiotoracovascolare, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), Università di Trieste, 34128 Trieste, ItalyDipartimento Cardiotoracovascolare, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), Università di Trieste, 34128 Trieste, ItalyIstituto di Fisiologia Clinica—CNR, 54100 Massa, ItalyOnassis Cardiac Surgery Center, 17674 Athens, GreeceIstituto di Radiologia, Dipartimento di Medicina, Università di Padova, 35128 Padova, ItalyDepartment of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, ItalyIstituto di Radiologia, Dipartimento di Medicina, Università di Padova, 35128 Padova, ItalyBackground/Objectives: We aimed to establish biatrial and biventricular reference ranges using cardiac magnetic resonance (CMR) parameters in SCD patients without heart damage. Methods: This study compared CMR parameters, quantified by cine SSFP sequences, in 48 adult SCD patients without apparent cardiac involvement (defined by the absence of known risk factors, normal electrocardiogram, and no macroscopic myocardial fibrosis or significant cardiac iron on T2* CMR) to matched cohorts of 96 healthy controls and 96 thalassemia major (TM) patients without cardiac damage. Nine paediatric SCD patients were also analysed and compared to age- and gender-matched groups of nine TM patients and nine healthy subjects. Results: In all groups, studied males displayed higher biventricular volumes and mass indexes than females. Male SCD patients showed significantly higher left ventricular (LV) end-diastolic volume index (EDVI), LV end-systolic volume index (ESVI), LV stroke volume index (SVI), cardiac index, LV and right ventricular (RV) mass index, and atrial areas than healthy subjects. Females with SCD exhibited increased LV EDVI, LV SVI, RV mass index, and left atrial area index compared to healthy controls. SCD and TM patients showed comparable biatrial areas and biventricular volumes and function. When compared to TM, SCD males exhibited a larger mass index, while SCD females showed an increased RV mass index. CMR parameters were similar across all paediatric groups. Conclusions: By establishing the biatrial and biventricular reference ranges through CMR for adult male and female SCD patients, we aimed to prevent possible misdiagnosis of cardiomyopathy in this population by taking into account cardiac adaptation due to anaemia.https://www.mdpi.com/2075-4418/14/24/2816sickle cell diseasecardiac magnetic resonancebiventricular volumes |
| spellingShingle | Laura Pistoia Antonella Meloni Vincenzo Positano Alessandra Quota Elisabetta Corigliano Giuseppe Messina Stefania Renne Michela Zerbini Simona Romani Gianfranco Sinagra Lamia Ait Ali Sophie Mavrogeni Amalia Lupi Filippo Cademartiri Alessia Pepe Biatrial and Biventricular Reference Ranges Based on Cardiac Magnetic Resonance in Sickle Cell Disease Patients Without Heart Damage Diagnostics sickle cell disease cardiac magnetic resonance biventricular volumes |
| title | Biatrial and Biventricular Reference Ranges Based on Cardiac Magnetic Resonance in Sickle Cell Disease Patients Without Heart Damage |
| title_full | Biatrial and Biventricular Reference Ranges Based on Cardiac Magnetic Resonance in Sickle Cell Disease Patients Without Heart Damage |
| title_fullStr | Biatrial and Biventricular Reference Ranges Based on Cardiac Magnetic Resonance in Sickle Cell Disease Patients Without Heart Damage |
| title_full_unstemmed | Biatrial and Biventricular Reference Ranges Based on Cardiac Magnetic Resonance in Sickle Cell Disease Patients Without Heart Damage |
| title_short | Biatrial and Biventricular Reference Ranges Based on Cardiac Magnetic Resonance in Sickle Cell Disease Patients Without Heart Damage |
| title_sort | biatrial and biventricular reference ranges based on cardiac magnetic resonance in sickle cell disease patients without heart damage |
| topic | sickle cell disease cardiac magnetic resonance biventricular volumes |
| url | https://www.mdpi.com/2075-4418/14/24/2816 |
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