Transcutaneous bilirubin nomogram for Taiwanese newborns – A single center study
Background: Hour-specific bilirubin nomogram has been recommended to predict postdischarge hyperbilirubinemia in newborns. However, it may not be applicable in Taiwan due to ethnic differences. The aim of this study was to construct a 12-h specific transcutaneous bilirubin (TCB) nomogram in newborns...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-06-01
|
| Series: | Pediatrics and Neonatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957218300202 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849322710857940992 |
|---|---|
| author | Tung-Hua Chen Yung-Chieh Lin Yuh-Jyh Lin Chyi-Her Lin |
| author_facet | Tung-Hua Chen Yung-Chieh Lin Yuh-Jyh Lin Chyi-Her Lin |
| author_sort | Tung-Hua Chen |
| collection | DOAJ |
| description | Background: Hour-specific bilirubin nomogram has been recommended to predict postdischarge hyperbilirubinemia in newborns. However, it may not be applicable in Taiwan due to ethnic differences. The aim of this study was to construct a 12-h specific transcutaneous bilirubin (TCB) nomogram in newborns for clinical reference. Methods: We prospectively enrolled full term or late preterm neonates born in a tertiary care hospital between October 2013 and July 2014. The exclusion criteria included chromosome anomaly, glucose-6-phosphate dehydrogenase deficiency, and receiving phototherapy within 60 h after birth. TCB measurements were performed by a single technician using the Bilichek device, and measured every 12 h until neonates were discharged. Patient data including sex, delivery mode, gestational age, body weight with daily change, and feeding pattern were collected for analysis. A TCB nomogram was constructed with 40th, 75th, and 95th percentile lines. Results: A total of 498 newborns were enrolled, and the characteristics between the hyperbilirubinemia and nonhyperbilirubinemia groups were not different. The mean TCB curve revealed that the peak TCB level was 14.2 ± 2.9 mg/dL at 100.6 ± 3.6 h of age. The peak 95th percentile TCB level was 19.4 mg/dL at 121.9 ± 5 h of age. Mean TCB levels increased at a rate of 0.01–0.21 mg/dL/h initially, followed by a decrease after 96–108 h of age. Twenty newborns (4%) were diagnosed with hyperbilirubinemia. Regarding TCB distribution, 11 of 60 (18%) had peak TCB levels above the 95th percentile, 5 of 151 (3%) had TCB levels between the 75th and 95th percentile, 4 of 200 (2%) had levels between the 40th and 75th percentiles, and none had a level below the 40th percentile. Conclusion: A 12-h specific TCB nomogram could be a useful reference for workup for hyperbilirubinemia, particularly when it is above the 95th percentile line. Key Words: hyperbilirubinemia, nomogram, transcutaneous bilirubin |
| format | Article |
| id | doaj-art-6e46e99c720c48e2ba94e93ae4e39ef5 |
| institution | Kabale University |
| issn | 1875-9572 |
| language | English |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-6e46e99c720c48e2ba94e93ae4e39ef52025-08-20T03:49:17ZengElsevierPediatrics and Neonatology1875-95722019-06-0160329129610.1016/j.pedneo.2018.07.013Transcutaneous bilirubin nomogram for Taiwanese newborns – A single center studyTung-Hua Chen0Yung-Chieh Lin1Yuh-Jyh Lin2Chyi-Her Lin3Department of Pediatrics, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan; Jin-Sin Women and Children's Hospital, Tainan, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Pediatrics, E-Da Hospital, Kaohsiung, Taiwan; Corresponding author. Department of Pediatrics, E-Da Hospital, #1 Yi-Da Road, Jiaosu Village, Yachao District, Kaohsiung, 82445, Taiwan.Background: Hour-specific bilirubin nomogram has been recommended to predict postdischarge hyperbilirubinemia in newborns. However, it may not be applicable in Taiwan due to ethnic differences. The aim of this study was to construct a 12-h specific transcutaneous bilirubin (TCB) nomogram in newborns for clinical reference. Methods: We prospectively enrolled full term or late preterm neonates born in a tertiary care hospital between October 2013 and July 2014. The exclusion criteria included chromosome anomaly, glucose-6-phosphate dehydrogenase deficiency, and receiving phototherapy within 60 h after birth. TCB measurements were performed by a single technician using the Bilichek device, and measured every 12 h until neonates were discharged. Patient data including sex, delivery mode, gestational age, body weight with daily change, and feeding pattern were collected for analysis. A TCB nomogram was constructed with 40th, 75th, and 95th percentile lines. Results: A total of 498 newborns were enrolled, and the characteristics between the hyperbilirubinemia and nonhyperbilirubinemia groups were not different. The mean TCB curve revealed that the peak TCB level was 14.2 ± 2.9 mg/dL at 100.6 ± 3.6 h of age. The peak 95th percentile TCB level was 19.4 mg/dL at 121.9 ± 5 h of age. Mean TCB levels increased at a rate of 0.01–0.21 mg/dL/h initially, followed by a decrease after 96–108 h of age. Twenty newborns (4%) were diagnosed with hyperbilirubinemia. Regarding TCB distribution, 11 of 60 (18%) had peak TCB levels above the 95th percentile, 5 of 151 (3%) had TCB levels between the 75th and 95th percentile, 4 of 200 (2%) had levels between the 40th and 75th percentiles, and none had a level below the 40th percentile. Conclusion: A 12-h specific TCB nomogram could be a useful reference for workup for hyperbilirubinemia, particularly when it is above the 95th percentile line. Key Words: hyperbilirubinemia, nomogram, transcutaneous bilirubinhttp://www.sciencedirect.com/science/article/pii/S1875957218300202 |
| spellingShingle | Tung-Hua Chen Yung-Chieh Lin Yuh-Jyh Lin Chyi-Her Lin Transcutaneous bilirubin nomogram for Taiwanese newborns – A single center study Pediatrics and Neonatology |
| title | Transcutaneous bilirubin nomogram for Taiwanese newborns – A single center study |
| title_full | Transcutaneous bilirubin nomogram for Taiwanese newborns – A single center study |
| title_fullStr | Transcutaneous bilirubin nomogram for Taiwanese newborns – A single center study |
| title_full_unstemmed | Transcutaneous bilirubin nomogram for Taiwanese newborns – A single center study |
| title_short | Transcutaneous bilirubin nomogram for Taiwanese newborns – A single center study |
| title_sort | transcutaneous bilirubin nomogram for taiwanese newborns a single center study |
| url | http://www.sciencedirect.com/science/article/pii/S1875957218300202 |
| work_keys_str_mv | AT tunghuachen transcutaneousbilirubinnomogramfortaiwanesenewbornsasinglecenterstudy AT yungchiehlin transcutaneousbilirubinnomogramfortaiwanesenewbornsasinglecenterstudy AT yuhjyhlin transcutaneousbilirubinnomogramfortaiwanesenewbornsasinglecenterstudy AT chyiherlin transcutaneousbilirubinnomogramfortaiwanesenewbornsasinglecenterstudy |