Resting cortisol concentrations in dogs presenting to a university teaching hospital with collapse
Abstract Background The relationship between collapse and a diagnosis of hypoadrenocorticism is not well understood in dogs. Hypothesis To assess the prevalence of episodes of collapse in dogs screened for hypoadrenocorticism, and to assess the prevalence of confirmed hypoadrenocorticism in dogs pre...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.17214 |
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| author | Ana Fernandez Gallego Craig Robert Breheny Adam G. Gow Alisdair M. Boag |
| author_facet | Ana Fernandez Gallego Craig Robert Breheny Adam G. Gow Alisdair M. Boag |
| author_sort | Ana Fernandez Gallego |
| collection | DOAJ |
| description | Abstract Background The relationship between collapse and a diagnosis of hypoadrenocorticism is not well understood in dogs. Hypothesis To assess the prevalence of episodes of collapse in dogs screened for hypoadrenocorticism, and to assess the prevalence of confirmed hypoadrenocorticism in dogs presenting with reported collapse. Animals Seventy‐three client‐owned dogs with resting cortisol concentrations were measured and presented to a University teaching hospital for collapse. Methods Retrospective review of medical records of dogs at a single center. Results The prevalence of episodes of collapse in dogs that had a resting cortisol measurement was 73/856 (8.5%; 95% confidence interval [95% CI], 6.7%‐10.6%). Resting cortisol concentration was <2 μg/dL (<55 nmol/L) in 19 dogs. Cortisol concentration after ACTH stimulation was <2 μg/dL (<55 nmol/L) in 1 of the 73 dogs in this cohort, consistent with a diagnosis of hypoadrenocorticism, giving a prevalence estimate of hypoadrenocorticism of 1.3% (95% CI, 0.15%‐6.2%). In 8 dogs with an initial resting cortisol concentration <2 μg/dL (<55 nmol/L), hypoadrenocorticism was excluded based on a repeat resting cortisol concentration >2 μg/dL (>55 nmol/L). The most common diagnosis was vasovagal syncope (10/73), followed by sick sinus syndrome and third‐degree atrioventricular block (2/73). The final diagnosis was unknown in 24/73 dogs. Conclusions and Clinical Importance Hypoadrenocorticism was the final diagnosis in 1 of 73 dogs presented to a teaching hospital either in a collapsed state or with a previous history of episodes of collapse. No dog presenting as cardiovascularly stable for intermittent collapse was found to have hypoadrenocorticism. |
| format | Article |
| id | doaj-art-6e3c9be88596414f8fd8cc7baf3fb0cf |
| institution | Kabale University |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-6e3c9be88596414f8fd8cc7baf3fb0cf2024-11-25T08:31:40ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762024-11-013863025303010.1111/jvim.17214Resting cortisol concentrations in dogs presenting to a university teaching hospital with collapseAna Fernandez Gallego0Craig Robert Breheny1Adam G. Gow2Alisdair M. Boag3The Royal (Dick) School of Veterinary Studies and the Roslin Institute Easter Bush Campus, The University of Edinburgh Midlothian UKThe Royal (Dick) School of Veterinary Studies and the Roslin Institute Easter Bush Campus, The University of Edinburgh Midlothian UKThe Royal (Dick) School of Veterinary Studies and the Roslin Institute Easter Bush Campus, The University of Edinburgh Midlothian UKThe Royal (Dick) School of Veterinary Studies and the Roslin Institute Easter Bush Campus, The University of Edinburgh Midlothian UKAbstract Background The relationship between collapse and a diagnosis of hypoadrenocorticism is not well understood in dogs. Hypothesis To assess the prevalence of episodes of collapse in dogs screened for hypoadrenocorticism, and to assess the prevalence of confirmed hypoadrenocorticism in dogs presenting with reported collapse. Animals Seventy‐three client‐owned dogs with resting cortisol concentrations were measured and presented to a University teaching hospital for collapse. Methods Retrospective review of medical records of dogs at a single center. Results The prevalence of episodes of collapse in dogs that had a resting cortisol measurement was 73/856 (8.5%; 95% confidence interval [95% CI], 6.7%‐10.6%). Resting cortisol concentration was <2 μg/dL (<55 nmol/L) in 19 dogs. Cortisol concentration after ACTH stimulation was <2 μg/dL (<55 nmol/L) in 1 of the 73 dogs in this cohort, consistent with a diagnosis of hypoadrenocorticism, giving a prevalence estimate of hypoadrenocorticism of 1.3% (95% CI, 0.15%‐6.2%). In 8 dogs with an initial resting cortisol concentration <2 μg/dL (<55 nmol/L), hypoadrenocorticism was excluded based on a repeat resting cortisol concentration >2 μg/dL (>55 nmol/L). The most common diagnosis was vasovagal syncope (10/73), followed by sick sinus syndrome and third‐degree atrioventricular block (2/73). The final diagnosis was unknown in 24/73 dogs. Conclusions and Clinical Importance Hypoadrenocorticism was the final diagnosis in 1 of 73 dogs presented to a teaching hospital either in a collapsed state or with a previous history of episodes of collapse. No dog presenting as cardiovascularly stable for intermittent collapse was found to have hypoadrenocorticism.https://doi.org/10.1111/jvim.17214ACTH stimulation testAddison's diseasecollapsing episodeshypoadrenocorticism |
| spellingShingle | Ana Fernandez Gallego Craig Robert Breheny Adam G. Gow Alisdair M. Boag Resting cortisol concentrations in dogs presenting to a university teaching hospital with collapse Journal of Veterinary Internal Medicine ACTH stimulation test Addison's disease collapsing episodes hypoadrenocorticism |
| title | Resting cortisol concentrations in dogs presenting to a university teaching hospital with collapse |
| title_full | Resting cortisol concentrations in dogs presenting to a university teaching hospital with collapse |
| title_fullStr | Resting cortisol concentrations in dogs presenting to a university teaching hospital with collapse |
| title_full_unstemmed | Resting cortisol concentrations in dogs presenting to a university teaching hospital with collapse |
| title_short | Resting cortisol concentrations in dogs presenting to a university teaching hospital with collapse |
| title_sort | resting cortisol concentrations in dogs presenting to a university teaching hospital with collapse |
| topic | ACTH stimulation test Addison's disease collapsing episodes hypoadrenocorticism |
| url | https://doi.org/10.1111/jvim.17214 |
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