Exploring the efficiency of Oxone®/KI as a promoter in the synthesis of spirocyclopropylbarbiturate derivatives via Michael-initiated reaction cyclization (MIRC)
This study investigates the innovative use of Oxone®/KI as a a promoter in synthesizing spirocyclopropylbarbiturate (SCPB) derivatives via the Michael-initiated reaction cyclization (MIRC) process. The synthesis involves aromatic aldehydes, malononitrile, barbituric acid, Oxone®/KI, and sodium aceta...
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| Language: | English |
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Elsevier
2025-07-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625004771 |
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| author | Amin Rezaeifard Eskandar Kolvari Nadiya Koukabi |
| author_facet | Amin Rezaeifard Eskandar Kolvari Nadiya Koukabi |
| author_sort | Amin Rezaeifard |
| collection | DOAJ |
| description | This study investigates the innovative use of Oxone®/KI as a a promoter in synthesizing spirocyclopropylbarbiturate (SCPB) derivatives via the Michael-initiated reaction cyclization (MIRC) process. The synthesis involves aromatic aldehydes, malononitrile, barbituric acid, Oxone®/KI, and sodium acetate in a water-ethanol mixture under standard conditions. This novel approach offers several key advantages, including a notably simplified purification process, milder reaction conditions, and significantly improved yields. These attributes contribute to greater efficiency, reduced labor intensity, and enhanced safety during synthesis. Importantly, the method also aligns with the principles of green chemistry, minimizing hazardous reagent use and waste generation. Collectively, these benefits position the Oxone®/KI system as a highly effective and environmentally responsible strategy for spirobarbiturate synthesis. The structural integrity of the synthesized derivatives was confirmed using FT-IR, 1H NMR, and 13C NMR spectroscopic techniques. |
| format | Article |
| id | doaj-art-6e37d1d84a2c40cda298200fe874a059 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-6e37d1d84a2c40cda298200fe874a0592025-08-20T03:59:30ZengElsevierResults in Chemistry2211-71562025-07-011610249410.1016/j.rechem.2025.102494Exploring the efficiency of Oxone®/KI as a promoter in the synthesis of spirocyclopropylbarbiturate derivatives via Michael-initiated reaction cyclization (MIRC)Amin Rezaeifard0Eskandar Kolvari1Nadiya Koukabi2Department of Chemistry, Semnan University, Semnan 35131-19111, IranCorresponding author.; Department of Chemistry, Semnan University, Semnan 35131-19111, IranDepartment of Chemistry, Semnan University, Semnan 35131-19111, IranThis study investigates the innovative use of Oxone®/KI as a a promoter in synthesizing spirocyclopropylbarbiturate (SCPB) derivatives via the Michael-initiated reaction cyclization (MIRC) process. The synthesis involves aromatic aldehydes, malononitrile, barbituric acid, Oxone®/KI, and sodium acetate in a water-ethanol mixture under standard conditions. This novel approach offers several key advantages, including a notably simplified purification process, milder reaction conditions, and significantly improved yields. These attributes contribute to greater efficiency, reduced labor intensity, and enhanced safety during synthesis. Importantly, the method also aligns with the principles of green chemistry, minimizing hazardous reagent use and waste generation. Collectively, these benefits position the Oxone®/KI system as a highly effective and environmentally responsible strategy for spirobarbiturate synthesis. The structural integrity of the synthesized derivatives was confirmed using FT-IR, 1H NMR, and 13C NMR spectroscopic techniques.http://www.sciencedirect.com/science/article/pii/S2211715625004771Aromatic aldehydesBarbituric acidMalononitrileMichael-initiated reaction cyclization (MIRC)Oxone®/KISpirocyclopropylbarbiturate (SCPB) derivatives |
| spellingShingle | Amin Rezaeifard Eskandar Kolvari Nadiya Koukabi Exploring the efficiency of Oxone®/KI as a promoter in the synthesis of spirocyclopropylbarbiturate derivatives via Michael-initiated reaction cyclization (MIRC) Results in Chemistry Aromatic aldehydes Barbituric acid Malononitrile Michael-initiated reaction cyclization (MIRC) Oxone®/KI Spirocyclopropylbarbiturate (SCPB) derivatives |
| title | Exploring the efficiency of Oxone®/KI as a promoter in the synthesis of spirocyclopropylbarbiturate derivatives via Michael-initiated reaction cyclization (MIRC) |
| title_full | Exploring the efficiency of Oxone®/KI as a promoter in the synthesis of spirocyclopropylbarbiturate derivatives via Michael-initiated reaction cyclization (MIRC) |
| title_fullStr | Exploring the efficiency of Oxone®/KI as a promoter in the synthesis of spirocyclopropylbarbiturate derivatives via Michael-initiated reaction cyclization (MIRC) |
| title_full_unstemmed | Exploring the efficiency of Oxone®/KI as a promoter in the synthesis of spirocyclopropylbarbiturate derivatives via Michael-initiated reaction cyclization (MIRC) |
| title_short | Exploring the efficiency of Oxone®/KI as a promoter in the synthesis of spirocyclopropylbarbiturate derivatives via Michael-initiated reaction cyclization (MIRC) |
| title_sort | exploring the efficiency of oxone r ki as a promoter in the synthesis of spirocyclopropylbarbiturate derivatives via michael initiated reaction cyclization mirc |
| topic | Aromatic aldehydes Barbituric acid Malononitrile Michael-initiated reaction cyclization (MIRC) Oxone®/KI Spirocyclopropylbarbiturate (SCPB) derivatives |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625004771 |
| work_keys_str_mv | AT aminrezaeifard exploringtheefficiencyofoxonekiasapromoterinthesynthesisofspirocyclopropylbarbituratederivativesviamichaelinitiatedreactioncyclizationmirc AT eskandarkolvari exploringtheefficiencyofoxonekiasapromoterinthesynthesisofspirocyclopropylbarbituratederivativesviamichaelinitiatedreactioncyclizationmirc AT nadiyakoukabi exploringtheefficiencyofoxonekiasapromoterinthesynthesisofspirocyclopropylbarbituratederivativesviamichaelinitiatedreactioncyclizationmirc |