3-bromo-4-(2-hydroxyethyl)-7-methoxy-2H-chromen-2-one inhibits allergic reactions in IgE-mediated RBL-2H3 cells and a passive cutaneous anaphylaxis mouse model

3-bromo-4-(2-hydroxyethyl)-7-methoxy-2H-chromen-2-one inhibits allergic reactions in IgE-mediated RBL-2H3 cells and a passive cutaneous anaphylaxis mouse model

Abstract Allergic reactions occur when the immune system overreacts to generally harmless substances, leading to both acute and chronic diseases, which can be fatal. Mast cells are critical mediators of allergic reactions as they bind allergens and trigger the release of inflammatory mediators. In t...

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Bibliographic Details
Main Authors: Moonsu Kim, Huiji Kim, Sun Young Moon, Seong-Ah Shin, Minji Kim, Seyeon Choi, Sugeun Gwon, Jun Hyuck Lee, Hyun Ho Park, Chang Sup Lee
Format: Article
Language:English
Published: SpringerOpen 2025-01-01
Series:Applied Biological Chemistry
Subjects:
Allergy
Mast cells
3-Bromo-4-(2-Hydroxyethyl)-7-Methoxy-2H-Chromen-2-One
Anti-Allergic therapeutics
AKT pathway
MAPK pathway
Online Access:https://doi.org/10.1186/s13765-025-00979-x
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