Development and Validation of a Patient Model for Simulating Anaesthetic Uptake
Mathematical patient models play a profound role in the managing and understanding of anaesthesia. This article proposes a patient model for simulating anaesthetic uptake, i.e. the storing of anaesthetic gases in the human body, thus extending a well known four compartment model from literature. Rea...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-12-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2024-2041 |
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| _version_ | 1846096872957018112 |
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| author | Demgensky Clara Hennigs Carlotta Kater Andreas Bargstädt Björn Rostalski Philipp |
| author_facet | Demgensky Clara Hennigs Carlotta Kater Andreas Bargstädt Björn Rostalski Philipp |
| author_sort | Demgensky Clara |
| collection | DOAJ |
| description | Mathematical patient models play a profound role in the managing and understanding of anaesthesia. This article proposes a patient model for simulating anaesthetic uptake, i.e. the storing of anaesthetic gases in the human body, thus extending a well known four compartment model from literature. Real time data is used for the simulation, from which the sevoflurane concentration is extracted. The exhaled concentrations from the model and the data are compared. A literature model is extended with ratios of compartmental perfusion, the introduction of coefficients representing diffusion and the change of the solubility coefficient. The extended and the literature model are applied to five training data sets, with prior optimization of the parameters that have the most impact. Afterwards, both models are validated on five additional data sets. The results of the extended model are mostly better than the results of the literature model. Therefore, the extensions improve the model for the used data, but need to be validated with a larger amount of data. |
| format | Article |
| id | doaj-art-6e16f945b47c40f4b4b49ffa0f62347a |
| institution | Kabale University |
| issn | 2364-5504 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj-art-6e16f945b47c40f4b4b49ffa0f62347a2025-01-02T05:56:33ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042024-12-0110417117410.1515/cdbme-2024-2041Development and Validation of a Patient Model for Simulating Anaesthetic UptakeDemgensky Clara0Hennigs Carlotta1Kater Andreas2Bargstädt Björn3Rostalski Philipp4Institute for Electrical Engineering in Medicine, Universitat zu Lubeck,Lubeck, GermanyInstitute for Electrical Engineering in Medicine, Universitat zu Lubeck,Lubeck, GermanyDragerwerk AG & Co. KGaA,Lubeck, GermanyDragerwerk AG & Co. KGaA,Lubeck, GermanyInstitute for Electrical Engineering in Medicine, Universitat zu Lubeck,Lubeck, GermanyMathematical patient models play a profound role in the managing and understanding of anaesthesia. This article proposes a patient model for simulating anaesthetic uptake, i.e. the storing of anaesthetic gases in the human body, thus extending a well known four compartment model from literature. Real time data is used for the simulation, from which the sevoflurane concentration is extracted. The exhaled concentrations from the model and the data are compared. A literature model is extended with ratios of compartmental perfusion, the introduction of coefficients representing diffusion and the change of the solubility coefficient. The extended and the literature model are applied to five training data sets, with prior optimization of the parameters that have the most impact. Afterwards, both models are validated on five additional data sets. The results of the extended model are mostly better than the results of the literature model. Therefore, the extensions improve the model for the used data, but need to be validated with a larger amount of data.https://doi.org/10.1515/cdbme-2024-2041patient modelvolatile anaestheticssevofluraneinhalational anaesthesiasimulation |
| spellingShingle | Demgensky Clara Hennigs Carlotta Kater Andreas Bargstädt Björn Rostalski Philipp Development and Validation of a Patient Model for Simulating Anaesthetic Uptake Current Directions in Biomedical Engineering patient model volatile anaesthetics sevoflurane inhalational anaesthesia simulation |
| title | Development and Validation of a Patient Model for Simulating Anaesthetic Uptake |
| title_full | Development and Validation of a Patient Model for Simulating Anaesthetic Uptake |
| title_fullStr | Development and Validation of a Patient Model for Simulating Anaesthetic Uptake |
| title_full_unstemmed | Development and Validation of a Patient Model for Simulating Anaesthetic Uptake |
| title_short | Development and Validation of a Patient Model for Simulating Anaesthetic Uptake |
| title_sort | development and validation of a patient model for simulating anaesthetic uptake |
| topic | patient model volatile anaesthetics sevoflurane inhalational anaesthesia simulation |
| url | https://doi.org/10.1515/cdbme-2024-2041 |
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