Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential
Phosphatidylserine (PS), the most abundant anionic phospholipid in cell membrane, is strictly confined to the inner leaflet in normal cells. However, this PS asymmetry is found disruptive in many tumor vascular endothelial cells. We discuss the underlying mechanisms for PS asymmetry maintenance in n...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-05-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012117708722 |
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| _version_ | 1841564464781983744 |
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| author | Lulu Wang MD, PhD Amyn A. Habib MD Akiva Mintz MD, PhD King C. Li MD Dawen Zhao MD, PhD |
| author_facet | Lulu Wang MD, PhD Amyn A. Habib MD Akiva Mintz MD, PhD King C. Li MD Dawen Zhao MD, PhD |
| author_sort | Lulu Wang MD, PhD |
| collection | DOAJ |
| description | Phosphatidylserine (PS), the most abundant anionic phospholipid in cell membrane, is strictly confined to the inner leaflet in normal cells. However, this PS asymmetry is found disruptive in many tumor vascular endothelial cells. We discuss the underlying mechanisms for PS asymmetry maintenance in normal cells and its loss in tumor cells. The specificity of PS exposure in tumor vasculature but not normal blood vessels may establish it a useful biomarker for cancer molecular imaging. Indeed, utilizing PS-targeting antibodies, multiple imaging probes have been developed and multimodal imaging data have shown their high tumor-selective targeting in various cancers. There is a critical need for improved diagnosis and therapy for brain tumors. We have recently established PS-targeted nanoplatforms, aiming to enhance delivery of imaging contrast agents across the blood–brain barrier to facilitate imaging of brain tumors. Advantages of using the nanodelivery system, in particular, lipid-based nanocarriers, are discussed here. We also describe our recent research interest in developing PS-targeted nanotheranostics for potential image-guided drug delivery to treat brain tumors. |
| format | Article |
| id | doaj-art-6dd75921a92a47e8b29041ba331a14e5 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-6dd75921a92a47e8b29041ba331a14e52025-01-02T22:38:05ZengSAGE PublishingMolecular Imaging1536-01212017-05-011610.1177/153601211770872210.1177_1536012117708722Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic PotentialLulu Wang MD, PhD0Amyn A. Habib MD1Akiva Mintz MD, PhD2King C. Li MD3Dawen Zhao MD, PhD4 Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, USA North Texas VA Medical Center, Dallas, TX, USA Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA Clinical and Translational Science Institute, Wake Forest School of Medicine, Winston-Salem, NC, USA North Texas VA Medical Center, Dallas, TX, USAPhosphatidylserine (PS), the most abundant anionic phospholipid in cell membrane, is strictly confined to the inner leaflet in normal cells. However, this PS asymmetry is found disruptive in many tumor vascular endothelial cells. We discuss the underlying mechanisms for PS asymmetry maintenance in normal cells and its loss in tumor cells. The specificity of PS exposure in tumor vasculature but not normal blood vessels may establish it a useful biomarker for cancer molecular imaging. Indeed, utilizing PS-targeting antibodies, multiple imaging probes have been developed and multimodal imaging data have shown their high tumor-selective targeting in various cancers. There is a critical need for improved diagnosis and therapy for brain tumors. We have recently established PS-targeted nanoplatforms, aiming to enhance delivery of imaging contrast agents across the blood–brain barrier to facilitate imaging of brain tumors. Advantages of using the nanodelivery system, in particular, lipid-based nanocarriers, are discussed here. We also describe our recent research interest in developing PS-targeted nanotheranostics for potential image-guided drug delivery to treat brain tumors.https://doi.org/10.1177/1536012117708722 |
| spellingShingle | Lulu Wang MD, PhD Amyn A. Habib MD Akiva Mintz MD, PhD King C. Li MD Dawen Zhao MD, PhD Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential Molecular Imaging |
| title | Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential |
| title_full | Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential |
| title_fullStr | Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential |
| title_full_unstemmed | Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential |
| title_short | Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential |
| title_sort | phosphatidylserine targeted nanotheranostics for brain tumor imaging and therapeutic potential |
| url | https://doi.org/10.1177/1536012117708722 |
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