Immune cells mediate the association between the plasma lipidome and pancreatic cancer: a Mendelian randomization analysis

Immune cells mediate the association between the plasma lipidome and pancreatic cancer: a Mendelian randomization analysis

Abstract The plasma liposome was associated with pancreatic cancer (PC) but the specific mechanism was still unclear. We aim to investigate the relationship between the plasma lipidome and PC risk, as well as the mediating roles of immune cells. Based on summary genome-wide association study (GWAS)...

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Bibliographic Details
Main Authors: Chunhong Ma, Dandan Liu, Changchun Ye, Zilu Chen, Ranran Kong, Jianzhong Li, Xuejun Sun, Zhengshui Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Mendelian randomization analysis
Plasma lipidome
Pancreatic cancer
Immune cell
Online Access:https://doi.org/10.1038/s41598-025-05898-x
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