Enhanced cerebral oxygenation during mental and physical activity in older adults is unaltered by amnestic mild cognitive impairment
BackgroundThe impact of amnestic mild cognitive impairment (aMCI) on cerebral oxygenation and cardiovascular responses to mental and physical challenges in elderly adults is unclear. This study compared the responses to mental (serial sevens test) and physical (isometric handgrip) challenges in olde...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1535045/full |
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| author | Stephanie Elbanna Christopher Cortez Elaina Smith Jewelia Rattanavong Sarah Ross Geoffrey Kline April Wiechmann Hannah Dyson Robert T. Mallet Xiangrong Shi |
| author_facet | Stephanie Elbanna Christopher Cortez Elaina Smith Jewelia Rattanavong Sarah Ross Geoffrey Kline April Wiechmann Hannah Dyson Robert T. Mallet Xiangrong Shi |
| author_sort | Stephanie Elbanna |
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| description | BackgroundThe impact of amnestic mild cognitive impairment (aMCI) on cerebral oxygenation and cardiovascular responses to mental and physical challenges in elderly adults is unclear. This study compared the responses to mental (serial sevens test) and physical (isometric handgrip) challenges in older adults with vs. without aMCI.MethodsThirty-one aMCI (71.5 ± 1.1 years old) and 30 cognitively normal (70.8 ± 1.1 years old) adults participated in the study. Heart rate (HR), mean arterial pressure (MAP), systemic arterial oxygen saturation (SaO2), prefrontal cortical oxyhemoglobin (O2Hb) and deoxyhemoglobin (HHb) contents, and tissue oxygen saturation (ScO2) were continuously monitored during 2-min serial sevens mental arithmetic test and 1-min isometric handgrip at 30% of maximal voluntary contraction. Test results in the aMCI vs. non-MCI subjects were compared by two-factor ANOVA.ResultsCardiovascular and tissue oxygenation responses to testing were similar in the two groups. Although MAP increased similarly during the mental and physical challenges, increases in HR (P = 0.020), SaO2 (P < 0.001), ScO2 (P = 0.001) and O2Hb (P = 0.022) were greater during the mental vs. physical challenges in both aMCI and cognitively normal subjects.ConclusionThe mental arithmetic challenge increased the metabolic demand of the prefrontal cortex to a greater extent than the physical task. Cerebral O2 content increased more appreciably during the mental vs. physical challenges, in parallel with greater increases in HR. However, aMCI did not alter these physiological responses to mental or physical challenges. |
| format | Article |
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| institution | Kabale University |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Physiology |
| spelling | doaj-art-6d95a1cd9dbe4114b42f842660dba8312025-08-20T03:53:13ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-05-011610.3389/fphys.2025.15350451535045Enhanced cerebral oxygenation during mental and physical activity in older adults is unaltered by amnestic mild cognitive impairmentStephanie Elbanna0Christopher Cortez1Elaina Smith2Jewelia Rattanavong3Sarah Ross4Geoffrey Kline5April Wiechmann6Hannah Dyson7Robert T. Mallet8Xiangrong Shi9Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United StatesDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United StatesDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United StatesDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United StatesDepartment of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, United StatesDepartment of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, United StatesDepartment of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, United StatesDepartment of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, United StatesDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United StatesDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United StatesBackgroundThe impact of amnestic mild cognitive impairment (aMCI) on cerebral oxygenation and cardiovascular responses to mental and physical challenges in elderly adults is unclear. This study compared the responses to mental (serial sevens test) and physical (isometric handgrip) challenges in older adults with vs. without aMCI.MethodsThirty-one aMCI (71.5 ± 1.1 years old) and 30 cognitively normal (70.8 ± 1.1 years old) adults participated in the study. Heart rate (HR), mean arterial pressure (MAP), systemic arterial oxygen saturation (SaO2), prefrontal cortical oxyhemoglobin (O2Hb) and deoxyhemoglobin (HHb) contents, and tissue oxygen saturation (ScO2) were continuously monitored during 2-min serial sevens mental arithmetic test and 1-min isometric handgrip at 30% of maximal voluntary contraction. Test results in the aMCI vs. non-MCI subjects were compared by two-factor ANOVA.ResultsCardiovascular and tissue oxygenation responses to testing were similar in the two groups. Although MAP increased similarly during the mental and physical challenges, increases in HR (P = 0.020), SaO2 (P < 0.001), ScO2 (P = 0.001) and O2Hb (P = 0.022) were greater during the mental vs. physical challenges in both aMCI and cognitively normal subjects.ConclusionThe mental arithmetic challenge increased the metabolic demand of the prefrontal cortex to a greater extent than the physical task. Cerebral O2 content increased more appreciably during the mental vs. physical challenges, in parallel with greater increases in HR. However, aMCI did not alter these physiological responses to mental or physical challenges.https://www.frontiersin.org/articles/10.3389/fphys.2025.1535045/fullcerebral tissue oxygenationheart rate responseisometric handgripneurovascular couplingoxyhemoglobinserial sevens test |
| spellingShingle | Stephanie Elbanna Christopher Cortez Elaina Smith Jewelia Rattanavong Sarah Ross Geoffrey Kline April Wiechmann Hannah Dyson Robert T. Mallet Xiangrong Shi Enhanced cerebral oxygenation during mental and physical activity in older adults is unaltered by amnestic mild cognitive impairment Frontiers in Physiology cerebral tissue oxygenation heart rate response isometric handgrip neurovascular coupling oxyhemoglobin serial sevens test |
| title | Enhanced cerebral oxygenation during mental and physical activity in older adults is unaltered by amnestic mild cognitive impairment |
| title_full | Enhanced cerebral oxygenation during mental and physical activity in older adults is unaltered by amnestic mild cognitive impairment |
| title_fullStr | Enhanced cerebral oxygenation during mental and physical activity in older adults is unaltered by amnestic mild cognitive impairment |
| title_full_unstemmed | Enhanced cerebral oxygenation during mental and physical activity in older adults is unaltered by amnestic mild cognitive impairment |
| title_short | Enhanced cerebral oxygenation during mental and physical activity in older adults is unaltered by amnestic mild cognitive impairment |
| title_sort | enhanced cerebral oxygenation during mental and physical activity in older adults is unaltered by amnestic mild cognitive impairment |
| topic | cerebral tissue oxygenation heart rate response isometric handgrip neurovascular coupling oxyhemoglobin serial sevens test |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1535045/full |
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