Targeting KRAS: from metabolic regulation to cancer treatment

Targeting KRAS: from metabolic regulation to cancer treatment

Abstract The Kirsten rat sarcoma viral oncogene homolog (KRAS) protein plays a key pathogenic role in oncogenesis, cancer progression, and metastasis. Numerous studies have explored the role of metabolic alterations in KRAS-driven cancers, providing a scientific rationale for targeting metabolism in...

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Bibliographic Details
Main Authors: Yanyan Shi, Huiling Zheng, Tianzhen Wang, Shengpu Zhou, Shiqing Zhao, Mo Li, Baoshan Cao
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Cancer
Subjects:
KRAS-driven cancers
Cancer metabolism
KRAS inhibitors
Metabolic reprogramming
Online Access:https://doi.org/10.1186/s12943-024-02216-3
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