Leukotrienes E4 and B4 and vascular endothelium – New insight into the link between vascular inflammation and peripheral arterial
Leukotrienes are proinflammatory mediators that participate in the process of atherogenesis and contribute to the development of symptomatic peripheral arterial disease. The aim was to evaluate the relationship between leukotriene E4 (LTE4) and B4 (LTB4) with parameters reflecting endothelial vascul...
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Elsevier
2024-12-01
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| Series: | International Journal of Cardiology. Cardiovascular Risk and Prevention |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772487524001089 |
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| author | Paweł Maga Agnieszka Wachsmann-Maga Aleksandra Włodarczyk Mikołaj Maga Krzysztof Batko Katarzyna Bogucka Maria Kapusta Piotr Terlecki |
| author_facet | Paweł Maga Agnieszka Wachsmann-Maga Aleksandra Włodarczyk Mikołaj Maga Krzysztof Batko Katarzyna Bogucka Maria Kapusta Piotr Terlecki |
| author_sort | Paweł Maga |
| collection | DOAJ |
| description | Leukotrienes are proinflammatory mediators that participate in the process of atherogenesis and contribute to the development of symptomatic peripheral arterial disease. The aim was to evaluate the relationship between leukotriene E4 (LTE4) and B4 (LTB4) with parameters reflecting endothelial vascular function in patients with chronic lower limb ischemia. This prospective observational study enrolled 50 consecutive patients undergoing endovascular treatment due to chronic lower limb ischemia (Rutherford 3). All participants were followed-up for one year (after 1, 3, 6 and 12 months), with a sequential assessment of urinary LTE4 and LTB4, as well as measures of endothelial and vascular function: Flow-Mediated Dilatation (FMD), Intima-Media Thickness (IMT), corrected Augmentation Index (AI75), Shear Rate (SR), Ankle-Brachial Index (ABI), Toe-Brachial Index (TBI). There was a significant relationship between LTE4 and measures of vascular function: FMD (R2 = 0.69, P < 0.001), IMT (R2 = 0.12, P < 0.01), AI75 (R2 = 0.43, P < 0.001), SR (R2 = 0.48, P < 0.001). Similar findings were noted for LTB4: FMD (R2 = 0.47, p < 0.001), IMT (R2 = 0.23, P < 0.001), AI75 (R2 = 0.61, P < 0.001) and SR (R2 = 0.33, P < 0.001). Alterations in parameters were significantly related: ΔLTE4 vs ΔFMD(R2 = 0.63, P < 0.001), ΔSR (R2 = 0.42, P < 0.001) and ΔLTB4 vs AI75(R2 = 0.40, P < 0.001), SR(R2 = 0. 29, P < 0.001). We conclude, that increasing concentrations of LTE4 and LTB4 are associated with impairment of vascular and endothelial function, which may lead to worse endovascular treatment clinical outcomes. |
| format | Article |
| id | doaj-art-6cfeabbfff564764aa6bb967a02e863e |
| institution | Kabale University |
| issn | 2772-4875 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| spelling | doaj-art-6cfeabbfff564764aa6bb967a02e863e2024-11-28T04:35:24ZengElsevierInternational Journal of Cardiology. Cardiovascular Risk and Prevention2772-48752024-12-0123200343Leukotrienes E4 and B4 and vascular endothelium – New insight into the link between vascular inflammation and peripheral arterialPaweł Maga0Agnieszka Wachsmann-Maga1Aleksandra Włodarczyk2Mikołaj Maga3Krzysztof Batko4Katarzyna Bogucka5Maria Kapusta6Piotr Terlecki7Department of Angiology, Medical Faculty, Jagiellonian University Medical College, Krakow, Poland; Clinical Department of Angiology, University Hospital in Krakow, PolandDepartment of Angiology, Medical Faculty, Jagiellonian University Medical College, Krakow, Poland; Clinical Department of Angiology, University Hospital in Krakow, PolandDepartment of Angiology, Medical Faculty, Jagiellonian University Medical College, Krakow, PolandClinical Department of Angiology, University Hospital in Krakow, Poland; Corresponding author. ul. Jakubowskiego 2, 30Krakow, Poland.Department of Research and Design, Medicine Economy Law Society (MELS) Foundation, Krakow, PolandClinical Department of Angiology, University Hospital in Krakow, PolandDepartment of Diagnostics, Chair of Clinical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Krakow, PolandDepartment of Vascular Surgery and Angiology, Medical University of Lublin, PolandLeukotrienes are proinflammatory mediators that participate in the process of atherogenesis and contribute to the development of symptomatic peripheral arterial disease. The aim was to evaluate the relationship between leukotriene E4 (LTE4) and B4 (LTB4) with parameters reflecting endothelial vascular function in patients with chronic lower limb ischemia. This prospective observational study enrolled 50 consecutive patients undergoing endovascular treatment due to chronic lower limb ischemia (Rutherford 3). All participants were followed-up for one year (after 1, 3, 6 and 12 months), with a sequential assessment of urinary LTE4 and LTB4, as well as measures of endothelial and vascular function: Flow-Mediated Dilatation (FMD), Intima-Media Thickness (IMT), corrected Augmentation Index (AI75), Shear Rate (SR), Ankle-Brachial Index (ABI), Toe-Brachial Index (TBI). There was a significant relationship between LTE4 and measures of vascular function: FMD (R2 = 0.69, P < 0.001), IMT (R2 = 0.12, P < 0.01), AI75 (R2 = 0.43, P < 0.001), SR (R2 = 0.48, P < 0.001). Similar findings were noted for LTB4: FMD (R2 = 0.47, p < 0.001), IMT (R2 = 0.23, P < 0.001), AI75 (R2 = 0.61, P < 0.001) and SR (R2 = 0.33, P < 0.001). Alterations in parameters were significantly related: ΔLTE4 vs ΔFMD(R2 = 0.63, P < 0.001), ΔSR (R2 = 0.42, P < 0.001) and ΔLTB4 vs AI75(R2 = 0.40, P < 0.001), SR(R2 = 0. 29, P < 0.001). We conclude, that increasing concentrations of LTE4 and LTB4 are associated with impairment of vascular and endothelial function, which may lead to worse endovascular treatment clinical outcomes.http://www.sciencedirect.com/science/article/pii/S2772487524001089EndotheliumLeukotrienesVascular inflammationPeripheral arterial disease |
| spellingShingle | Paweł Maga Agnieszka Wachsmann-Maga Aleksandra Włodarczyk Mikołaj Maga Krzysztof Batko Katarzyna Bogucka Maria Kapusta Piotr Terlecki Leukotrienes E4 and B4 and vascular endothelium – New insight into the link between vascular inflammation and peripheral arterial International Journal of Cardiology. Cardiovascular Risk and Prevention Endothelium Leukotrienes Vascular inflammation Peripheral arterial disease |
| title | Leukotrienes E4 and B4 and vascular endothelium – New insight into the link between vascular inflammation and peripheral arterial |
| title_full | Leukotrienes E4 and B4 and vascular endothelium – New insight into the link between vascular inflammation and peripheral arterial |
| title_fullStr | Leukotrienes E4 and B4 and vascular endothelium – New insight into the link between vascular inflammation and peripheral arterial |
| title_full_unstemmed | Leukotrienes E4 and B4 and vascular endothelium – New insight into the link between vascular inflammation and peripheral arterial |
| title_short | Leukotrienes E4 and B4 and vascular endothelium – New insight into the link between vascular inflammation and peripheral arterial |
| title_sort | leukotrienes e4 and b4 and vascular endothelium new insight into the link between vascular inflammation and peripheral arterial |
| topic | Endothelium Leukotrienes Vascular inflammation Peripheral arterial disease |
| url | http://www.sciencedirect.com/science/article/pii/S2772487524001089 |
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