Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections

Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections

IntroductionZika virus (ZIKV) and dengue virus (DENV) are mosquito-borne flaviviruses associated with serious neurological complications, such as Guillain-Barré syndrome and congenital Zika syndrome (ZIKV), as well as encephalitis, meningitis, and stroke (DENV). Despite their growing public health i...

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Main Authors: José De Jesus Bravo-Silva, Ricardo Jimenez-Camacho, Magda Lizbeth Benítez-Vega, Jonathan Hernández-Castillo, Carlos Daniel Cordero-Rivera, Carlos Noe Farfan-Morales, Marcos Pérez-García, Raymundo Cruz, Rosa María del Ángel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
inflammation
melatonin
brain
cerebellum
viral infection
ZIKV
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1630116/full
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