Integrated spatial and single cell transcriptomics identifies PRKDC as a dual prognostic biomarker and therapeutic target in hepatocellular carcinoma

Integrated spatial and single cell transcriptomics identifies PRKDC as a dual prognostic biomarker and therapeutic target in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with a pressing need for effective biomarkers and therapeutic targets. Despite the clinical use of alpha-fetoprotein (AFP) as a diagnostic biomarker, its limitations in sensitivity and specificity necessitate the...

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Bibliographic Details
Main Authors: Wenpeng Pang, Yunyong Wang, Xiaohang Lu, Minpeng Li, Fuli Long, Songlin Chen, Yuan Yu, Mingfen Li, Hongsheng Lin
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Hepatocellular carcinoma
PRKDC
Therapeutic target
Tumor microenvironment
Multi-omics analysis
Online Access:https://doi.org/10.1038/s41598-025-98866-4
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