Value of alpha smooth muscle actin (αSMA) and inducible nitric oxide synthase (iNOS) in oral squamous cell carcinoma (OSCC): An immunohistochemical approach to tumor stroma categorization and clinicopathological parameters

Value of alpha smooth muscle actin (αSMA) and inducible nitric oxide synthase (iNOS) in oral squamous cell carcinoma (OSCC): An immunohistochemical approach to tumor stroma categorization and clinicopathological parameters

Objectives: The aggressive behavior of oral squamous cell carcinoma (OSCC) is not only a cancer-cell centered issue, but also affected by tumor stroma. Cancer-associated fibroblasts (CAFs) are the most abundant component of tumor stroma that can direct tumorigenesis. Alpha smooth muscle actin (α-SMA...

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Bibliographic Details
Main Authors: Heba E.M. Youssef, Basant Hamdy AbouZaid
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Oral Oncology Reports
Subjects:
CAFs
OSCC
α-SMA
iNOS
Stromal categorization
Online Access:http://www.sciencedirect.com/science/article/pii/S2772906025000068
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