Subverting <i>Attachment</i> to Prevent <i>Attacking</i>: Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion
Cell adhesion regulates specific migratory patterns, location, communication with other cells, physical interactions with the extracellular matrix, and the establishment of effector programs. Proper immune control of cancer strongly depends on all these events occurring in a highly accurate spatiote...
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MDPI AG
2024-10-01
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| Series: | Biology |
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| author | Marta Mastrogiovanni Emmanuel Donnadieu Rajiv Pathak Vincenzo Di Bartolo |
| author_facet | Marta Mastrogiovanni Emmanuel Donnadieu Rajiv Pathak Vincenzo Di Bartolo |
| author_sort | Marta Mastrogiovanni |
| collection | DOAJ |
| description | Cell adhesion regulates specific migratory patterns, location, communication with other cells, physical interactions with the extracellular matrix, and the establishment of effector programs. Proper immune control of cancer strongly depends on all these events occurring in a highly accurate spatiotemporal sequence. In response to cancer-associated inflammatory signals, effector immune cells navigating the bloodstream shift from their patrolling exploratory migration mode to establish adhesive interactions with vascular endothelial cells. This interaction enables them to extravasate through the blood vessel walls and access the cancer site. Further adhesive interactions within the tumor microenvironment (TME) are crucial for coordinating their distribution in situ and for mounting an effective anti-tumor immune response. In this review, we examine how alterations of adhesion cues in the tumor context favor tumor escape by affecting effector immune cell infiltration and trafficking within the TME. We discuss the mechanisms by which tumors directly modulate immune cell adhesion and migration patterns to affect anti-tumor immunity and favor tumor evasion. We also explore indirect immune escape mechanisms that involve modifications of TME characteristics, such as vascularization, immunogenicity, and structural topography. Finally, we highlight the significance of these aspects in designing more effective drug treatments and cellular immunotherapies. |
| format | Article |
| id | doaj-art-6cd9d6f23216420ba4b5039f7ebf0385 |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-6cd9d6f23216420ba4b5039f7ebf03852024-11-26T17:52:14ZengMDPI AGBiology2079-77372024-10-01131186010.3390/biology13110860Subverting <i>Attachment</i> to Prevent <i>Attacking</i>: Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune EvasionMarta Mastrogiovanni0Emmanuel Donnadieu1Rajiv Pathak2Vincenzo Di Bartolo3Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USAEquipe Labellisée Ligue Contre le Cancer, CNRS, INSERM, Institut Cochin, Université Paris Cité, F-75014 Paris, FranceDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USAImmunoregulation Unit, Institut Pasteur, Université Paris Cité, F-75015 Paris, FranceCell adhesion regulates specific migratory patterns, location, communication with other cells, physical interactions with the extracellular matrix, and the establishment of effector programs. Proper immune control of cancer strongly depends on all these events occurring in a highly accurate spatiotemporal sequence. In response to cancer-associated inflammatory signals, effector immune cells navigating the bloodstream shift from their patrolling exploratory migration mode to establish adhesive interactions with vascular endothelial cells. This interaction enables them to extravasate through the blood vessel walls and access the cancer site. Further adhesive interactions within the tumor microenvironment (TME) are crucial for coordinating their distribution in situ and for mounting an effective anti-tumor immune response. In this review, we examine how alterations of adhesion cues in the tumor context favor tumor escape by affecting effector immune cell infiltration and trafficking within the TME. We discuss the mechanisms by which tumors directly modulate immune cell adhesion and migration patterns to affect anti-tumor immunity and favor tumor evasion. We also explore indirect immune escape mechanisms that involve modifications of TME characteristics, such as vascularization, immunogenicity, and structural topography. Finally, we highlight the significance of these aspects in designing more effective drug treatments and cellular immunotherapies.https://www.mdpi.com/2079-7737/13/11/860effector immune cellsimmune cell biologyleukocyte adhesionleukocyte migrationtumor microenvironment |
| spellingShingle | Marta Mastrogiovanni Emmanuel Donnadieu Rajiv Pathak Vincenzo Di Bartolo Subverting <i>Attachment</i> to Prevent <i>Attacking</i>: Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion Biology effector immune cells immune cell biology leukocyte adhesion leukocyte migration tumor microenvironment |
| title | Subverting <i>Attachment</i> to Prevent <i>Attacking</i>: Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion |
| title_full | Subverting <i>Attachment</i> to Prevent <i>Attacking</i>: Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion |
| title_fullStr | Subverting <i>Attachment</i> to Prevent <i>Attacking</i>: Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion |
| title_full_unstemmed | Subverting <i>Attachment</i> to Prevent <i>Attacking</i>: Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion |
| title_short | Subverting <i>Attachment</i> to Prevent <i>Attacking</i>: Alteration of Effector Immune Cell Migration and Adhesion as a Key Mechanism of Tumor Immune Evasion |
| title_sort | subverting i attachment i to prevent i attacking i alteration of effector immune cell migration and adhesion as a key mechanism of tumor immune evasion |
| topic | effector immune cells immune cell biology leukocyte adhesion leukocyte migration tumor microenvironment |
| url | https://www.mdpi.com/2079-7737/13/11/860 |
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