Aerobic exercise attenuates high-fat diet-induced glycometabolism impairments in skeletal muscle of rat: role of EGR-1/PTP1B signaling pathway

Aerobic exercise attenuates high-fat diet-induced glycometabolism impairments in skeletal muscle of rat: role of EGR-1/PTP1B signaling pathway

Abstract Objective Impaired skeletal muscle glycogen synthesis contributes to insulin resistance (IR). Aerobic exercise reported to ameliorate IR by augmenting insulin signaling, however the detailed mechanism behind this improvement remains unclear. This study investigated whether aerobic exercise...

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Bibliographic Details
Main Authors: Liangzhi Zhang, Xiaojie Liu, Jing Hu, Helong Quan, Sang Ki Lee, Mallikarjuna Korivi, Lifeng Wang, Ting Li, Wei Li
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Nutrition & Metabolism
Subjects:
Glycometabolism
Insulin sensitivity
Treadmill running
Glycogen synthesis
GLUT4
IRS1
Online Access:https://doi.org/10.1186/s12986-024-00888-8
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