Differential memory enrichment of cytotoxic CD4 T cells in Parkinson’s disease patients reactive to α-synuclein

Abstract Parkinson’s disease (PD) is a complex neurodegenerative disease with a largely unknown etiology. Although the loss of dopaminergic neurons in the substantia nigra pars compacta is the pathological hallmark of PD, neuroinflammation also plays a fundamental role in PD pathology. We have previ...

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Bibliographic Details
Main Authors: Antoine Freuchet, Emil Johansson, April Frazier, Irene Litvan, Jennifer G. Goldman, Roy N. Alcalay, David Sulzer, Cecilia S. Lindestam Arlehamn, Alessandro Sette
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00981-6
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